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首页> 外文期刊>BMC Neuroscience >Reliability of pain intensity clamping using response-dependent thermal stimulation in healthy volunteers
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Reliability of pain intensity clamping using response-dependent thermal stimulation in healthy volunteers

机译：使用响应依赖的热刺激对健康志愿者进行疼痛强度钳制的可靠性

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Background Pain intensity clamping uses the RE sponse- D ependent S timulation (REDSTIM) methodology to automatically adjust stimulus intensity to maintain a desired pain rating set-point which is continuously monitored from a subject’s real-time pain ratings. REDSTIM blinds subjects regarding the pain intensity set-point, supporting its use for assessing intervention efficacy. By maintaining the pain intensity at a constant level, a potential decrease in pain sensitivity can be detected by an increase in thermode temperature (unknown to the subject) and not by pain ratings alone. Further, previously described sensitizing and desensitizing trends within REDSTIM provide a novel insight into human pain mechanisms overcoming limitations of conventional testing methods. The purpose of the present study was to assess the test-retest reliability of pain intensity clamping using REDSTIM during three separate sessions. Methods We used a method for testing changes in pain sensitivity of human subjects (REDSTIM) where the stimulus temperature is modulated to clamp pain intensity near a desired set-point. Temperature serves as the response variable and is used to infer pain sensitivity. Several measures were analyzed for reliability including average temperature and area under the curve (AUC). Intraclass correlation coefficients were calculated for each measure at pain rating set-points of 20/100 and 35/100. Results Sixteen healthy individuals (mean age = 21.6 ± 3.9) participated in three experiments two days apart at both pain rating set-points. Most reliability coefficients were in the moderate to substantial range (r’s = 0.79 to 0.94) except for the negative AUC (r = 0.52), but only at the 20/100 pain rating set-point. Conclusions The present study supports the test-retest reliability of pain intensity clamping using the REDSTIM methodology while providing a novel tool to examine human pain modulatory mechanisms and overcoming common shortcomings of conventional quantitative sensory testing methods.
机译：背景疼痛强度钳制使用RE自主刺激（REDSTIM）方法来自动调整刺激强度，以维持所需的疼痛等级设定点，该设定点可根据受试者的实时疼痛等级进行连续监测。 REDSTIM使受试者无法了解疼痛强度设定点，从而支持其用于评估干预效果。通过将疼痛强度保持在恒定水平，可以通过热电极温度的升高（受试者不知道）而不是仅通过疼痛等级来检测疼痛敏感性的潜在降低。此外，先前描述的REDSTIM中的敏化和脱敏趋势为克服传统测试方法的局限性的人类疼痛机制提供了新颖的见解。本研究的目的是评估在三个单独的疗程中使用REDSTIM进行疼痛强度钳制的重测可靠性。方法我们使用一种方法来测试人类受试者的疼痛敏感性变化（REDSTIM），其中调节刺激温度以将疼痛强度钳制在所需的设定点附近。温度是响应变量，用于推断疼痛敏感性。分析了几种测量方法的可靠性，包括平均温度和曲线下面积（AUC）。在疼痛等级设定点为20/100和35/100的情况下，针对每种量度计算类内相关系数。结果16名健康个体（平均年龄= 21.6±3.9）在两个疼痛等级设定点相隔两天参加了三个实验。除负AUC（r = 0.52）外，大多数可靠性系数都在中度至较大范围内（r = 0.79至0.94），但仅在20/100疼痛等级设定点上。结论本研究支持使用REDSTIM方法进行疼痛强度钳制的重测可靠性，同时提供了一种新颖的工具来检查人的疼痛调节机制并克服了常规定量感觉测试方法的常见缺点。

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