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Leptin: role over central nervous system in epilepsy

机译：瘦素：在癫痫中对中枢神经系统的作用

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Adipose tissue is a dynamic organ with different effects on the body. Many of these effects are mediated by leptin, a hormone strongly involved in regulation of feeding and energy metabolism. It has an important role as a mediator of neuronal excitatory activity and higher brain functions. The aim of this study was to review the association between leptin and cerebral neuronal function, in particular its anticonvulsant or convulsant effects and the possible therapeutic role for treating epilepsy. For this purpose, the databases Pubmed, Science Direct, Elsevier, ResearchGate and Scielo were searched to identify experimental studies, reviews and systematic review articles, published in English, Spanish or Portuguese. Experimental studies and the presence of leptin receptors in nervous system sites other than the hypothalamus suggest an influence on higher brain functions. Indeed several animal studies have demonstrated a role of these channels in epileptiform activity as both anticonvulsive and convulsive effects have been found. The reason for these discrepancies is unclear but provides clear evidence of a potential role of leptin and leptin therapy in epileptiform activity. The association between leptin and brain function demonstrates the importance of peripheral metabolic hormones on central nervous system and opens a new way for the development of novel therapeutic interventions in diseases like epilepsy. Nevertheless further investigations are important to clarify the dynamics and diverse actions of leptin on excitatory regulation in the brain.
机译：脂肪组织是对人体有不同影响的动态器官。这些作用中有许多是由瘦素介导的，瘦素是一种强烈参与调节喂养和能量代谢的激素。它作为神经元兴奋性活动和更高的大脑功能的调节者具有重要作用。这项研究的目的是审查瘦素与大脑神经元功能之间的关联，特别是其抗惊厥或惊厥作用以及治疗癫痫的可能治疗作用。为此，搜索了Pubmed，Science Direct，Elsevier，ResearchGate和Scielo数据库，以鉴定以英语，西班牙语或葡萄牙语出版的实验研究，评论和系统评价文章。实验研究和瘦素受体在下丘脑以外的神经系统部位的存在表明对较高的脑功能有影响。确实，一些动物研究已经证明了这些通道在癫痫样活动中的作用，因为已经发现了抗惊厥和惊厥作用。这些差异的原因尚不清楚，但提供了瘦素和瘦素治疗在癫痫样活动中潜在作用的明确证据。瘦素与脑功能之间的联系证明了外周代谢激素对中枢神经系统的重要性，并为开发针对癫痫病等疾病的新型治疗手段开辟了新途径。然而，进一步的研究对于阐明瘦素对大脑兴奋性调节的动力学和多种作用很重要。

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