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首页> 外文期刊>BMC Pediatrics >Histopathological changes in anatomical distribution of inflammatory bowel disease in children: a retrospective cohort study
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Histopathological changes in anatomical distribution of inflammatory bowel disease in children: a retrospective cohort study

机译：儿童炎症性肠病的解剖分布的组织病理学变化：一项回顾性队列研究

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Background Anatomical progression of pediatric inflammatory bowel disease is under-reported. The aim of this work was to examine possible changes in the anatomical distribution of IBD in pediatric patients at diagnosis and at follow up. Methods In a retrospective cohort study, the medical records of children with inflammatory bowel disease were examined. Patients who had at least 2 endoscopic/colonoscopic examinations were included. Primary outcome was histopathological progression based on histopathological examination of biopsies taken during endoscopic and colonoscopic bowel examination. Factors predictive of disease progression were also examined. Results A total of 98 patients fulfilled inclusion criteria (49 female, 54 with ulcerative colitis, range 2 – 17 years, mean age at diagnosis was 10.6 years, SD ± 3.67), the mean duration of follow up was 32.9 months (range 0.1 – 60 months, SD ± 8.54). In the ulcerative colitis group, 41% had disease progression and none of the examined variables (age, gender, laboratory markers, growth and disease activity at diagnosis) appeared to effect disease progression. In the Crohn’s disease group, 75% had disease progression. Girls (OR = 0.13, 95% CI 0.02 – 0.79) and patients with high erythrocytic sedimentation rate (OR=0.942, 95% CI 0.894 – 0.99) were predictive for disease progression. Conclusions Despite maximum therapy, the majority of children with Crohn’s disease appeared to have histopathological disease progression. Female sex and high erythrocytic sedimentation rate seemed to be predictive for disease progression. None of the factors analyzed seemed predictive of disease progression in ulcerative colitis.
机译：背景小儿炎症性肠病的解剖学进展报道不足。这项工作的目的是检查在诊断和随访时小儿患者IBD解剖分布的可能变化。方法在一项回顾性队列研究中，对儿童炎症性肠病的病历进行了检查。包括至少两次内镜/结肠镜检查的患者。主要结果是根据在内窥镜和结肠镜检查时进行的活检组织病理学检查得出的组织病理学进展。还检查了预测疾病进展的因素。结果共有98位患者符合入选标准（49位女性，54位溃疡性结肠炎患者，范围2至17岁，诊断时平均年龄为10.6岁，SD±3.67），平均随访时间为32.9个月（范围为0.1 – 60个月，SD±8.54）。在溃疡性结肠炎组中，有41％的患者患有疾病进展，并且检查的变量（年龄，性别，实验室标记，生长和诊断时的疾病活动）均未显示影响疾病进展。在克罗恩病组中，有75％的人患有疾病。女孩（OR = 0.13，95％CI 0.02 – 0.79）和高红细胞沉降率（OR = 0.942，95％CI 0.894 – 0.99）的患者可预测疾病进展。结论尽管进行了最大程度的治疗，但大多数克罗恩氏病儿童似乎都有组织病理学疾病进展。女性和高红细胞沉降率似乎可以预测疾病的进展。分析的因素似乎都不能预测溃疡性结肠炎的疾病进展。

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