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首页> 外文期刊>BMC Neuroscience >Mice lacking galectin-3 ( Lgals3 ) function have decreased home cage movement
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Mice lacking galectin-3 ( Lgals3 ) function have decreased home cage movement

机译：缺乏galectin-3（Lgals3）功能的小鼠的笼内运动减少

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Galectins are a large family of proteins evolved to recognize specific carbohydrate moieties. Given the importance of pattern recognition processes for multiple biological tasks, including CNS development and immune recognition, we examined the home cage behavioral phenotype of mice lacking galectin-3 (Lgals3) function. Using a sophisticated monitoring apparatus capable of examining feeding, drinking, and movement at millisecond temporal and 0.5?cm spatial resolutions, we observed daily behavioral patterns from 10 wildtype male C57BL/6J and 10 Lgals3 constitutive knockout (Lgals3?/?; both cohorts aged 2–3?months) mice over 17 consecutive days. We performed a second behavioral assessment of this cohort at age 6–7?months. At both ages, Lgals3?/? mice demonstrated less movement compared to wildtype controls. Both forward locomotion and movement-in-place behaviors were decreased in Lgals3?/? mice, due to decreased bout numbers, initiation rates, and durations. We additionally noted perturbation of behavioral circadian rhythms in Lgals3?/? mice, with mice at both ages demonstrating greater variability in day-to-day performance of feeding, drinking, and movement (as assessed by Lomb-Scargle analysis) compared to wildtype. Carbohydrate recognition tasks performed by Lgals3 may be required for appropriate development of CNS structures involved in the generation and control of locomotor behavior.
机译：半乳凝素是进化为识别特定碳水化合物部分的一大类蛋白质。鉴于模式识别过程对于包括CNS发育和免疫识别在内的多种生物学任务的重要性，我们研究了缺乏半乳凝素3（Lgals3）功能的小鼠的笼形行为表型。使用能够在毫秒级时间和0.5？cm空间分辨率下检查进食，饮水和运动的先进监控设备，我们观察到来自10个野生型雄性C57BL / 6J和10个Lgals3组成型敲除的日常行为模式（Lgals3？/ ?;两个队列均年龄较大）连续17天的2至3个月）。我们在6-7个月大时对该队列进行了第二次行为评估。在两个年龄段，Lgals3？/？与野生型对照相比，小鼠表现出更少的运动。在Lgals3？/？中向前运动和就地移动行为均降低。小鼠，因为减少的发作次数，起始频率和持续时间。我们还注意到了Lgals3β/β中行为昼夜节律的摄动。与野生型相比，两个年龄段的小鼠在摄食，饮水和运动方面的日常表现都表现出更大的可变性（通过Lomb-Scargle分析评估）。由Lgals3执行的碳水化合物识别任务可能是参与运动行为的产生和控制所涉及的CNS结构的适当发展所必需的。

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