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首页> 外文期刊>BMC Pediatrics >Subcutaneous fat necrosis in neonates with hypoxic ischaemic encephalopathy registered in the Swiss National Asphyxia and Cooling Register
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Subcutaneous fat necrosis in neonates with hypoxic ischaemic encephalopathy registered in the Swiss National Asphyxia and Cooling Register

机译：在瑞士国家窒息和降温登记册中登记的新生儿缺氧缺血性脑病的皮下脂肪坏死

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Background Neonates with hypoxic ischaemic encephalopathy (HIE) are routinely treated with therapeutic hypothermia (TH) for 72?h in order to improve neurological outcome. Subcutaneous fat necrosis (SCFN) is an adverse event occurring in neonates with HIE. Methods We analyzed risk factors for SCFN regarding demographic factors, cooling methods and deviation from target temperature range during hypothermia therapy. Data of all neonates registered in the National Asphyxia and Cooling Register in Switzerland between 2011 and 2013 were analyzed. Results 2.8?% of all cooled neonates with HIE developed SCFN. Perinatal and neonatal characteristics did not differ between neonates with and without SCFN. Applied cooling methods did not correlate with the occurrence of SCFN. In neonates with SCFN 83.3?% of all noted temperatures were within the target temperature range versus 77.5?% in neonates without SCFN. Neonates with SCFN showed 3.6?% of all measured temperatures below target temperature range compared to 12.7?% in neonates without SCFN. Conclusion Subcutaneous fat necrosis in the neonate with HIE undergoing TH is a potential adverse event that seems to occur independently from the whole-body cooling method applied and proportion of temperature measurements outside target temperature range. In this cohort, moderate overcooling associated with moderate hypothermia (33.0–34.0?°C) does not seem to be an independent risk factor for SCFN. There is no correlation between the severity of HIE and incidence of SCFN.
机译：背景新生儿缺氧缺血性脑病（HIE）常规用治疗性体温过低（TH）治疗72 h，以改善神经功能。皮下脂肪坏死（SCFN）是发生在HIE新生儿中的不良事件。方法我们分析了低温治疗期间SCFN的危险因素，包括人口统计学因素，冷却方法以及与目标温度范围的偏差。分析了2011年至2013年在瑞士国家窒息与降温登记册中登记的所有新生儿的数据。结果所有HIE冷却的新生儿中有2.8％的人发展了SCFN。有和没有SCFN的新生儿的围产期和新生儿特征无差异。所应用的冷却方法与SCFN的发生无关。 SCFN新生儿的所有记录温度中，有83.3％的温度在目标温度范围内，而没有SCFN的新生儿中的77.5％在目标温度范围内。具有SCFN的新生儿显示所有测得的温度均低于目标温度范围的3.6％，而不含SCFN的新生儿为12.7％。结论HIE发生TH的新生儿皮下脂肪坏死是潜在的不良事件，似乎独立于采用的全身冷却方法和超出目标温度范围的温度测量比例而发生。在该队列中，中度低温与中度低温（33.0–34.0？°C）相关联似乎并不是SCFN的独立危险因素。 HIE的严重程度与SCFN的发生率之间没有相关性。

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