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首页> 外文期刊>BMC Pediatrics >Caregivers’ hair cortisol: a possible biomarker of chronic stress is associated with obesity measures among children with disabilities
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Caregivers’ hair cortisol: a possible biomarker of chronic stress is associated with obesity measures among children with disabilities

机译：照顾者的头发皮质醇：慢性压力的可能生物标志物与残疾儿童的肥胖措施有关

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Background The stress of caring for a loved one with chronic illness has been associated with childhood obesity. Hair cortisol has been proposed as a novel biomarker of chronic psychological stress. This study aimed to evaluate the associations between caregivers’ chronic stress evaluated by hair cortisol concentrations (HCC) and obesity measures among children with disabilities such as autism. Methods Eighty-five dyads of children with disabilities and their primary caregivers participated in the study between April and July 2013 in the Patagonia Region, Chile. Trained research staff conducted anthropometric measurements of children and caregivers. Cortisol concentrations, extracted from hair samples with methanol, were quantified using liquid chromatography tandem mass spectrometry. Pearson’s correlation coefficients and linear regression models were used to examine the associations between caregiver HCC (log-transformed) and child obesity measures with adjustment for covariates. Results Caregiver HCC were positively and significantly correlated with child weight (child age- and sex-adjusted r =0.23, P?=?0.036), body mass index (BMI) (r?=?0.23, P?=?0.035), circumferences of neck (r?=?0.30, P?=?0.006), waist (r?=?0.27, P?=?0.014), and hip (r?=?0.22, P?=?0.044). After adjustment for children’s age and sex, caregiver HCC were significantly related to child weight (kg) (beta?=?4.47, standard error (SE)?=?2.09), BMI (kg/m2) (beta?=?1.52, SE?=?0.71), neck circumference (cm) (beta?=?1.20, SE?=?0.43), waist circumference (cm) (beta?=?3.75, SE?=?1.50), and hip circumference (cm) (beta?=?3.02, SE?=?1.48). Caregiver HCC were also positively but not statistically significantly associated with child waist-to-hip ratio (beta?=?0.01, SE?=?0.01; P?=?0.191) or body fat percentage (%) (beta?=?2.11, SE?=?1.28; P?=?0.104). Further adjustment for other covariates including child disability diagnosis and caregiver age, sex, education, current smoking, perceived stress, and caregiver BMI did not change the results substantially. Conclusions Chronic stress of caregivers, evaluated by increased cortisol concentrations in hair, was positively associated with obesity measures among children with disabilities.
机译：背景技术照顾患有慢性病的亲人的压力与儿童肥胖有关。头发皮质醇已被提出作为慢性心理压力的新型生物标志物。这项研究旨在评估通过头发皮质醇浓度（HCC）评估的看护人的慢性压力与孤独症等残疾儿童的肥胖措施之间的关联。方法2013年4月至7月，在智利巴塔哥尼亚地区参加研究的八十五个残疾儿童及其主要照顾者。受过训练的研究人员对儿童和照顾者进行了人体测量。使用液相色谱串联质谱法对从毛发样品中用甲醇提取的皮质醇浓度进行定量。皮尔逊（Pearson）的相关系数和线性回归模型用于检验照顾者HCC（经对数转换）与儿童肥胖指标之间的相关性，并调整了协变量。结果看护者的肝癌与儿童体重（儿童年龄和性别校正后的r = 0.23，P≥0.036），体重指数（BMI）（r≥0.23，P≤0.035）呈显着正相关。脖子的周长（r≥0.30，P ＝ 0.006），腰（r≥0.27，P ＝ 0.014）和臀部（r≥0.22，P ＝ 0.044）。在调整了儿童的年龄和性别之后，看护者的肝癌与儿童体重（kg）（β？=？4.47，标准误（SE）？=？2.09），BMI（kg / m 2 ）显着相关。 ）（β≥1.52，SE≥0.71），脖子围（cm）（β≥1.20，SE≥0.43），腰围（cm）（β≥3.75，SE≥β）。 1.50）和臀围（cm）（β＝ 3.02，SE ＝ 1.48）。照料者HCC与儿童腰臀比（β？=？0.01，SE？=？0.01; P？=？0.191）或体脂百分比（％）（β？=？2.11）呈正相关但无统计学意义，SE≤1.28;P≤0.104）。对于其他协变量的进一步调整，包括儿童残疾诊断和看护者的年龄，性别，教育程度，当前吸烟状况，感知的压力和看护者的BMI并没有实质性改变结果。结论通过增加头发中的皮质醇浓度评估了看护人的慢性压力，与残疾儿童的肥胖措施呈正相关。

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