• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>BMC Pediatrics >Changes in hepatitis B virus antibody titers over time among children: a single center study from 2012 to 2015 in an urban of South Korea
【24h】

Changes in hepatitis B virus antibody titers over time among children: a single center study from 2012 to 2015 in an urban of South Korea

机译：儿童乙型肝炎病毒抗体滴度随时间的变化：2012年至2015年在韩国城市进行的单中心研究

获取原文
       
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Background Hepatitis B virus (HBV) infection is the most common cause of liver disease in endemic areas such as South Korea. After HBV vaccination, hepatitis B surface antibody (HBsAb) titers gradually decrease. Trends in HBsAb titers have not been evaluated among children in South Korea over the past decade. Methods We screened 6155 patients (aged 7?months to 17?years) who underwent HBV antigen/antibody testing at Chung-Ang University Hospital from May 2012 to April 2015. Titer criteria were defined as follows: positive, titer ≥100?IU/L; weakly positive, titer 10–99?IU/L; and negative, titer Results Of the 5655 patients included, 3016 were male and 5 (0.09%) tested positive for HBV surface antigen. A marked reduction in antibody titer was observed until 4?years of age. Thereafter, the titers showed fluctuating decreases. HBsAb titers reached their lowest levels by 14?years of age. After 7?years of age, 50% of patients tested negative for HBsAb. Simple linear analysis showed that the titer reached levels of n =?72), 69 children (96%) had developed antibodies while 3 (4%) remained HBsAb-negative. Conclusions In conclusion, the continuous reduction in HBsAb titers over time and in each age group was confirmed. The titer level was shown significant decline until age 4. More than half of the sample had negative titers after age 7?years. After booster vaccination, most of child significantly increase titer level.
机译：背景乙肝病毒（HBV）感染是韩国等流行地区最常见的肝病病因。乙肝疫苗接种后，乙肝表面抗体（HBsAb）滴度逐渐降低。在过去的十年中，尚未在韩国儿童中评估HBsAb滴度的趋势。方法我们筛选了2012年5月至2015年4月在中​​安大学医院接受HBV抗原/抗体检测的6155例患者（年龄7个月至17岁）。 L;弱阳性，滴度10-99？IU / L;滴度和阴性结果结果包括5655例患者，其中3016例为男性，其中5例（0.09％）检测为HBV表面抗原阳性。观察到抗体滴度显着降低，直至4岁。此后，效价显示波动降低。到14岁时，HBsAb滴度达到最低水平。 7岁后，50％的患者HBsAb呈阴性。简单的线性分析表明，滴度达到n =？72的水平，有69名儿童（96％）已产生抗体，而3名（4％）HBsAb阴性。结论总之，证实了随着时间的推移和各个年龄段HBsAb滴度的持续降低。直到4岁，滴度显示出显着下降。超过7岁的样品中，有一半以上的滴度为阴性。加强疫苗接种后，大多数儿童的效价水平显着提高。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号