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首页> 外文期刊>BMC Pediatrics >Long-term effects of vitamin D supplementation in vitamin D deficient obese children participating in an integrated weight-loss programme (a double-blind placebo-controlled study) – rationale for the study design
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Long-term effects of vitamin D supplementation in vitamin D deficient obese children participating in an integrated weight-loss programme (a double-blind placebo-controlled study) – rationale for the study design

机译：补充综合减肥计划（双盲安慰剂对照研究）的维生素D缺乏型肥胖儿童补充维生素D的长期效果–研究设计的理由

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Background Obesity is associated not only with an array of metabolic disorders (e.g. insulin resistance, hiperinsulinemia, impaired tolerance of glucose, lipid disorders) but also skeletal and joint abnormalities. Recently, a pleiotropic role of vitamin D has been emphasized. Obese children frequently present with vitamin D deficiency, and greater fat mass is associated with lower serum concentration of this vitamin. Although some evidence suggests that weight loss may affect vitamin D status, this issue has not been studied extensively thus far. The aim of a double-blind placebo-controlled study is to assess long-term health effects of vitamin D supplementation in vitamin D deficient obese children participating in an integrated weight-loss programme. Methods A randomized double-blind, placebo-controlled trial analysing the effects of vitamin D3 supplementation in overweight or obese vitamin D deficient (Discussion The effects of vitamin D supplementation in obese individuals, especially children, subjected to a weight-loss program are still poorly understood. Considering physiological processes associated with puberty and adolescent growth, we speculate that supplementation may enhance weight reduction and prevent bone loss in obese children deficient in this vitamin. Trial registration NCT 02828228 ; Trial registration date: 8 Jun 2016; Registered in: ClinicalTrials.gov. The trial was registered retrospectively.
机译：背景技术肥胖不仅与一系列代谢异常有关（例如胰岛素抵抗，胰岛素，血胰岛素，糖耐量减低，脂质异常），而且还与骨骼和关节异常有关。最近，已经强调了维生素D的多效作用。肥胖儿童经常出现维生素D缺乏症，而脂肪量增加与该维生素的血清浓度降低有关。尽管一些证据表明减肥可能会影响维生素D的状态，但到目前为止，尚未对该问题进行广泛的研究。一项双盲安慰剂对照研究的目的是评估参加综合减肥计划的维生素D缺乏型肥胖儿童补充维生素D的长期健康影响。方法：一项双盲，安慰剂对照的随机试验，分析了补充维生素D3对超重或肥胖的维生素D缺乏症的影响（讨论接受维生素D的肥胖人群，尤其是儿童，进行减肥计划的效果仍然较差）考虑到与青春期和青春期生长相关的生理过程，我们推测补充品可增强缺乏这种维生素的肥胖儿童的体重减轻并防止骨质流失，试验注册号NCT 02828228;试验注册日期：2016年6月8日;注册于：ClinicalTrials。 gov。该试验是回顾性注册的。

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