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首页> 外文期刊>BMC Pediatrics >Paracetamol use (and/or misuse) in children in Enugu, South-East, Nigeria
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Paracetamol use (and/or misuse) in children in Enugu, South-East, Nigeria

机译：尼日利亚东南部埃努古儿童对乙酰氨基酚的使用（和/或滥用）

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Background Paracetamol (also known as acetaminophen) is the commonest available analgesic and anti-pyretic. It is readily accessed from pharmacy, patent medicine and provision shops as over the counter drug making it a potential drug of abuse, especially in children. We sought to find its use and/or misuse in children seen at the paediatric outpatient clinic of the University of Nigeria Teaching Hospital (UNTH) Ituku-Ozalla, Enugu. Objective To determine the dosage, formulation, and frequency of paracetamol administration to children by caregivers and factors associated with its use and/or misuse. Method An observational prospective study involving 231 children and their caregivers seen at the paediatric outpatient clinic of the University of Nigeria Teaching Hospital, Ituku - Ozalla, Enugu between June and November 2011 was undertaken. Data on paracetamol use before presentation to the clinic, in addition to demographic and other data were obtained from the caregivers using a structured questionnaire. Ethical consent for the study was obtained from the Hospital Ethics and Research Committee and informed consent was further obtained from the caregivers of the children. Results A total of 231 children aged six weeks to 16?years and their caregivers participated in this study. The mean ages of the children and their caregivers were 3.8 and 33.9?years, respectively. One hundred and thirty three of the children studied were males while 98 were females. Most of the children (75.6%) received paracetamol at home before presenting. Paracetamol tablet alone or in combination with the syrup was mostly used (60%) and this observation was made across all age groups. The commonest reason for using paracetamol tablet instead of the syrup was that it was more effective. Most caregivers relied on past experience (71.2%) rather than on enclosed information leaflet to decide the appropriate dosage. Half of the children also received other medications, mainly anti-malarials and antibiotics. Conclusions Paracetamol was commonly given to children on “self prescription” basis and the tablet formulation was most frequently used, with the possibility of misuse and overdose. Caregivers need to be educated on age-appropriate formulations which are less likely to lead to overdose.
机译：背景对乙酰氨基酚（也称为对乙酰氨基酚）是最常用的止痛药和退热药。可以从药房，专利药和食品商店轻易获得，因为它是非处方药，这使其成为潜在的滥用药物，尤其是在儿童中。我们试图找到在尼日利亚大学教学医院（UNTH）伊图库-奥扎拉（Enuku）儿科门诊的儿童中使用和/或滥用的儿童。目的确定照护者及其使用和/或滥用相关因素对儿童服用扑热息痛的剂量，剂型和频率。方法于2011年6月至11月间，在尼日利亚大学教学医院的儿童门诊中对231名儿童及其照顾者进行了观察性前瞻性研究。就诊前，对乙酰氨基酚使用的数据以及人口统计资料和其他数据，是使用结构化问卷从看护人那里获得的。该研究的伦理学同意书是从医院伦理和研究委员会获得的，知情同意书是从这些孩子的照料者那里获得的。结果共有231名6周至16岁的儿童及其照顾者参加了这项研究。儿童及其照顾者的平均年龄分别为3.8岁和33.9岁。研究的儿童中有133名是男性，而98名是女性。出院前，大多数儿童（75.6％）在家中接受扑热息痛。单独使用扑热息痛片或与糖浆合用时占多数（60％），这一观察结果适用于所有年龄段。使用对乙酰氨基酚片代替糖浆的最常见原因是它更有效。大多数看护者是根据过去的经验（71.2％）来决定合适的剂量，而不是根据随附的信息单。一半的孩子还接受其他药物治疗，主要是抗疟疾和抗生素。结论扑热息痛通常以“自我处方”的方式给予儿童，并且最常使用这种片剂，有误用和过量的可能性。护理人员需要接受适合年龄的配方的教育，这种配方不太可能导致用药过量。

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