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首页> 外文期刊>BMC Pediatrics >Early characteristics of infants with pulmonary hypertension in a referral neonatal intensive care unit
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Early characteristics of infants with pulmonary hypertension in a referral neonatal intensive care unit

机译：转诊新生儿重症监护室中肺动脉高压婴儿的早期特征

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Background Approximately 8–23% of premature infants develop pulmonary hypertension (PH), and this diagnosis confers a higher possibility of mortality. As a result, professional societies recommend PH screening in premature infants. However, the risk factors for and the outcomes of PH may differ depending on the timing of its diagnosis, and little evidence is available to determine at-risk infants in the referral neonatal population.??The objective of this study was to define clinical and echocardiographic characteristics of infants with pulmonary hypertension during the neonatal hospital course and at or near-term?. Methods Infants who had the following billing codes: Results 556 infants were included in the overall study, 59 had PH on their final echocardiogram (11%). In multivariable analyses, atrial septal defect (2.9, 1.4–6.1), and intrauterine growth restriction (2.7, 1.2–6.3) increased the odds of late PH, whereas caffeine therapy decreased PH (0.4, 0.2–0.8). When the analyses were restricted to 32 infants who had multiple echocardiograms during their hospitalization, the association between atrial septal defect (5.9, 2.0–16.5) and growth restriction (3.7, 1.3–10.7) and late PH was strengthened, but the effect of caffeine therapy was no longer significant. In this smaller subgroup, infants with late PH had their final echocardiogram at a median of 116?days of life, and 42–74% of them had right ventricular pathology. Conclusions Early clinical variables are associated with PH persistence in a referral neonatal population. Identification of early clinical factors may help guide the ascertainment of infant risk for late PH, and may aid in targeting sub-groups that are most likely to benefit from PH screening.
机译：背景大约8–23％的早产儿发展为肺动脉高压（PH），这种诊断可赋予较高的死亡率。因此，专业协会建议对早产儿进行PH筛查。但是，PH的危险因素和结局可能因诊断时间而异，并且几乎没有证据可确定转诊新生儿人群中的高危婴儿。新生儿住院期间和近期的肺动脉高压婴儿的超声心动图特征。方法采用以下计费代码的婴儿：结果556例婴儿纳入了整个研究，其中59例的最终超声心动图为PH（11％）。在多变量分析中，房间隔缺损（2.9，1.4–6.1）和宫内生长受限（2.7，1.2–6.3）增加了晚期PH的几率，而咖啡因治疗则降低了PH（0.4，0.2–0.8）。当分析仅限于在住院期间接受多次超声心动图检查的32例婴儿时，房间隔缺损（5.9，2.0–16.5）与生长受限（3.7，1.3–10.7）和晚期PH之间的关联得到加强，但是咖啡因的作用增强了治疗不再重要。在这个较小的亚组中，患有晚期PH的婴儿的最终超声心动图处于中位生命116天，其中42-74％的患者患有右心室病变。结论早期临床变量与转诊新生儿人群的PH持续性有关。早期临床因素的识别可能有助于指导婴儿确定晚期PH的风险，并可能有助于确定最有可能从PH筛查中受益的亚人群。

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