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首页> 外文期刊>BMC Pediatrics >Prevalence, severity and early outcomes of hypoxic ischemic encephalopathy among newborns at a tertiary hospital, in northern Tanzania
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Prevalence, severity and early outcomes of hypoxic ischemic encephalopathy among newborns at a tertiary hospital, in northern Tanzania

机译：坦桑尼亚北部一家三级医院新生儿缺氧缺血性脑病的患病率，严重程度和早期结果

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Background Hypoxic Ischemic Encephalopathy (HIE) remains a problem of great concern worldwide especially in developing countries. The occurrence of a neurological syndrome can be an indicator of insult to the brain. We aimed to determine the prevalence, HIE proportions, neurological signs and early outcomes of newborns that developed birth asphyxia at KCMC Tanzania. Methods A prospective study was conducted at KCMC from November 2014 to April 2015 among newborns with birth asphyxia. Sarnat and Sarnat score was used to assess newborns immediately after birth to classify HIE and were later followed daily for 7?days or until discharge. Results Of the 1752 deliveries during the study period, 11.5% ( n =?201) had birth asphyxia. Of the 201 newborns, 187 had HIE. Of these 187 with HIE; 39.0% had moderate HIE and 10.2% had severe HIE according to the Sarnat and Sarnat classification. Neurological signs that were observed during the study period were; weak/absent reflexes (46.0%), hypotonia (43.3%) and lethargy (42.2%). Mortality was 9.1% among the 187 newborns with HIE. Mortality was higher among newborns with severe HIE 84.2% (16/19) compared to those with moderate HIE 1.4% (1/73). On the 7th day after delivery, 17.1% (32/187) of the newborns did not show any change from the initial score at delivery. Conclusion Prevalence of birth asphyxia is high in our setting and most of the newborns (49%) end up with moderate/severe HIE. Good obstetric care and immediate resuscitation of newborns are vital in reducing the occurrence of HIE and improving the general outcome of newborns.
机译：背景缺氧缺血性脑病（HIE）仍然是世界范围内极为关注的问题，尤其是在发展中国家。神经系统综合症的发生可能是对脑部侮辱的指示。我们旨在确定在坦桑尼亚KCMC发生窒息的新生儿的患病率，HIE比例，神经系统症状和早期结局。方法2014年11月至2015年4月在KCMC进行了一项前瞻性研究，研究对象为新生儿窒息。 Sarnat和Sarnat评分用于在出生后立即对新生儿进行评估，以对HIE进行分类，随后每天随访7天或直到出院。结果在研究期间的1752例分娩中，有11.5％（n =？201）患有出生性窒息。在201名新生儿中，有187名患有HIE。在这187个人中，有HIE;根据Sarnat和Sarnat分类，中度HIE占39.0％，重度HIE占10.2％。在研究期间观察到的神经系统症状是：弱反射/缺乏反射（46.0％），肌张力低下（43.3％）和嗜睡（42.2％）。在187例HIE新生儿中，死亡率为9.1％。重度HIE 84.2％（16/19）新生儿的死亡率高于中度HIE 1.4％（1/73）的新生儿。分娩后第7天，有17.1％（32/187）的新生儿与分娩时的初始评分没有任何变化。结论在我们的情况下，出生窒息的患病率很高，大多数新生儿（49％）最终患有中度/重度HIE。良好的产科护理和新生儿的立即复苏对于减少HIE的发生和改善新生儿的总体结局至关重要。

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