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首页> 外文期刊>BMC Pediatrics >Dexmedetomidine is effective and safe during NIV in infants and young children with acute respiratory failure
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Dexmedetomidine is effective and safe during NIV in infants and young children with acute respiratory failure

机译：右美托咪定在NIV期间对急性呼吸衰竭的婴幼儿有效且安全

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Noninvasive ventilation (NIV) is increasingly utilized in infants and young children, though associated with high failure rates due to agitation and poor compliance, mostly if patient-ventilator synchronization is required. A retrospective cohort study was carried out in an academic pediatric intensive care unit (PICU). Dexmedetomidine (DEX) was infused as unique sedative in 40 consecutive pediatric patients (median age 16?months) previously showing intolerance and agitation during NIV application. During NIV clinical application both COMFORT-B Score and Richmond Agitation-Sedation Scale (RASS) were serially evaluated. Four patients experiencing NIV failure, all due to pulmonary condition worsening, required intubation and invasive ventilation. 36 patients were successfully weaned from NIV under DEX sedation and discharged from PICU. All patients survived until home discharge. Our data suggest that DEX may represent an effective sedative agent in infants and children showing agitation during NIV. Early use of DEX in infants/children receiving NIV for acute respiratory failure (ARF) should be considered safe and capable of improving NIV, thus permitting both lung recruitment and patient-ventilator synchronization.
机译：尽管由于躁动和依从性差而导致的高失败率相关联，但无创通气（NIV）越来越多地用于婴幼儿，主要是在需要患者-呼吸机同步的情况下。在学术性儿科重症监护病房（PICU）中进行了一项回顾性队列研究。右美托咪定（DEX）被作为40例连续的儿科患者（中位年龄为16个月）的独特镇静剂注入，以前在NIV应用期间表现出不耐受和躁动。在NIV临床应用期间，对COMFORT-B评分和里士满躁动镇静量表（RASS）进行了连续评估。四名因肺部疾病恶化，需要插管和有创通气而发生NIV衰竭的患者。 36例患者在DEX镇静下成功从NIV断奶，并从PICU出院。所有患者存活直至出院。我们的数据表明，在NIV期间表现出躁动的婴儿和儿童中，DEX可能是一种有效的镇静剂。在接受NIV的急性呼吸衰竭（ARF）的婴幼儿中早期使用DEX应该被认为是安全且能够改善NIV的，因此可以同时招募肺和患者-呼吸机。

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