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Efficacy of levetiracetam for neonatal seizures in preterm infants

机译：左乙拉西坦对早产儿新生儿惊厥的疗效

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Neonatal seizures remain a significant clinical problem, and therapeutic options are still not diverse with limited efficacy. Levetiracetam (LEV) is a relatively new and wide spectrum anti-seizure medication with favorable pharmacokinetics and safety profile. In the recent decades, LEV has been increasingly used for the treatment of neonatal seizures. The aim of this study was to describe the experience of using LEV as the first line anti-seizure medication for preterm infants. A retrospective analysis of 37 preterm infants who were treated with LEV as the first-line anti-seizure medication was performed. Mean gestational age of the 37 preterm infants was 31.5?±?1.9?weeks (range, 26 to 36+?6 weeks). Twenty-one infants (57%) were seizure-free while given LEV at the end of the first week, and no additional anti-seizure medication was required. Loading doses of LEV ranged from 40 to 60?mg/kg (mean 56?mg/kg) and the maintenance dose ranged from 20 to 30?mg/kg (mean 23?mg/kg). No adverse effect was observed. Levetiracetam can be a good and safe choice for treatment of neonatal seizures in preterm infants. Prospective double blind controlled studies are needed in the future.
机译：新生儿癫痫发作仍然是一个重要的临床问题，并且治疗选择仍然不是多种多样的，疗效有限。左乙拉西坦（LEV）是一种相对较新的广谱抗癫痫药物，具有良好的药代动力学和安全性。在最近的几十年中，LEV已越来越多地用于治疗新生儿癫痫发作。这项研究的目的是描述使用LEV作为早产儿一线抗癫痫药的经验。回顾性分析了37例接受LEV作为一线抗癫痫药物治疗的早产儿。 37名早产儿的平均胎龄为31.5±1.9周，范围为26至36±6周。在第一周结束时给予LEV的21例婴儿（57％）无癫痫发作，并且不需要其他抗癫痫药治疗。 LEV的负荷剂量范围为40至60？mg / kg（平均56？mg / kg），维持剂量范围为20至30？mg / kg（平均23？mg / kg）。没有观察到不良影响。左乙拉西坦可以作为治疗早产儿新生儿惊厥的良好且安全的选择。未来需要前瞻性双盲对照研究。

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