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首页> 外文期刊>BMC Psychiatry >Alterations of hair cortisol and dehydroepiandrosterone in mother-infant-dyads with maternal childhood maltreatment
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Alterations of hair cortisol and dehydroepiandrosterone in mother-infant-dyads with maternal childhood maltreatment

机译：母婴期受母婴虐待的头发皮质醇和脱氢表雄酮的变化

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Background Child maltreatment (CM) has severe effects on psychological and physical health. The hypothalamic-pituitary-adrenal (HPA) axis, the major stress system of the body, is dysregulated after CM. The analysis of cortisol and dehydroepiandrosterone (DHEA) in scalp hair presents a new and promising methodological approach to assess chronic HPA axis activity. This study investigated the effects of CM on HPA axis activity in the last trimester of pregnancy by measuring the two important signaling molecules, cortisol and DHEA in hair, shortly after parturition. In addition, we explored potential effects of maternal CM on her offspring’s endocrine milieu during pregnancy by measuring cortisol and DHEA in newborns’ hair. Methods CM was assessed with the Childhood Trauma Questionnaire (CTQ). Cortisol and DHEA were measured in hair samples of 94 mothers and 30 newborns, collected within six days after delivery. Associations of maternal CM on her own and her newborn’s cortisol as well as DHEA concentrations in hair were analyzed with heteroscedastic regression models. Results Higher CM was associated with significantly higher DHEA levels, but not cortisol concentrations in maternal hair. Moreover, maternal CM was positively, but only as a non-significant trend, associated with higher DHEA levels in the newborns’ hair. Conclusions Results suggest that the steroid milieu of the mother, at least on the level of DHEA, is altered after CM, possibly leading to non-genomic transgenerational effects on the developing fetus in utero. Indeed, we observed on an explorative level first hints that the endocrine milieu for the developing child might be altered in CM mothers. These results need extension and replication in future studies. The measurement of hair steroids in mothers and their newborns is promising, but more research is needed to better understand the effects of a maternal history of CM on the developing fetus.
机译：背景儿童虐待（CM）对心理和身体健康有严重影响。下丘脑-垂体-肾上腺（HPA）轴是人体的主要压力系统，在CM后失调。头皮头发中的皮质醇和脱氢表雄酮（DHEA）的分析提出了一种新的有前途的方法学方法来评估慢性HPA轴活动。这项研究通过在分娩后不久测量头发中的两种重要信号分子皮质醇和DHEA，研究了CM对妊娠最后三个月HPA轴活性的影响。此外，我们通过测量新生儿头发中的皮质醇和DHEA，探讨了孕产妇CM对怀孕期间其后代内分泌环境的潜在影响。方法用儿童创伤问卷（CTQ）评估CM。在分娩后六天内收集的94名母亲和30名新生儿的头发样本中测量了皮质醇和DHEA。使用异方差回归模型分析了母体自身CM和新生儿的皮质醇以及头发中DHEA浓度的关联。结果较高的CM与DHEA水平明显升高有关，但与母发中的皮质醇浓度无关。此外，孕妇的CM呈阳性趋势，但趋势不明显，与新生儿头发中DHEA含量升高有关。结论结果表明，在CM后，母亲的类固醇环境至少在DHEA水平上发生了改变，这可能导致对子宫内胎儿的非基因组转基因作用。确实，我们在探索性水平上观察到，首先暗示，在CM母亲中，发育中儿童的内分泌环境可能会发生变化。这些结果需要在以后的研究中进行扩展和复制。对母亲及其新生儿的头发类固醇进行测量是有前途的，但需要进行更多的研究以更好地了解母亲的CM史对发育中的胎儿的影响。

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