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首页> 外文期刊>BMC Psychiatry >Retinoids, anxiety and peripartum depressive symptoms among Chinese women: a prospective cohort study
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Retinoids, anxiety and peripartum depressive symptoms among Chinese women: a prospective cohort study

机译：中国女性的类维生素A，焦虑症和围产期抑郁症状的前瞻性队列研究

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Background The current study aimed to investigate whether serum RBP levels can be a key predictor of peripartum depression (PPD). Methods This was a prospective cohort study, conducted at a general teaching hospital in South China. Research participants were evaluated at three time points: the third trimester of pregnancy (T1), after delivery at week one (T2), and after delivery week six (T3) using a set of self-reported questionnaires and blood sample assays. Results A total of 156 subjects were included for data analysis. The prevalence of anxiety symptoms ranged from 32.69% to 36.53%. The prevalence of PPD was also high and ranged from 27.56% to 35.89%. In the third trimester, significant predictors of depressive symptoms include serum retinol-binding protein (RBP) concentrations and estradiol levels ( P =?0.008 and 0.033, respectively). At one week after delivery, serum concentrations of RBP at T2 were still significant predictors of depressive symptoms ( P =?0.020, and serum estradiol concentrations at T1 were a significant predictor ( P =?0.010). The most stable predictor of depressive symptoms at T3 was anxiety symptoms, especially at T3 time point ( P Conclusion A high prevalence of anxiety and depressive symptoms tended to persist in Chinese women during the peripartum period. This study, which found the potential contribution of RBP to the occurrence of PPD, requires that large sample studies be conducted in future with a longer-term follow-up period, in order to confirm its results.
机译：背景技术本研究旨在调查血清RBP水平是否可以作为围产期抑郁症（PPD）的关键预测指标。方法这是一项前瞻性队列研究，在华南一家综合教学医院进行。在三个时间点对研究参与者进行了评估：妊娠晚期（T1），分娩后第一周（T2）和分娩后第六周（T3），使用一组自我报告的调查表和血液样本测定法。结果共纳入156名受试者进行数据分析。焦虑症状的患病率在32.69％至36.53％之间。 PPD的患病率也很高，介于27.56％至35.89％之间。在孕晚期，抑郁症状的重要预测指标包括血清视黄醇结合蛋白（RBP）浓度和雌二醇水平（分别为P = 0.008和0.033）。分娩后一周，R2的血清RBP浓度仍是抑郁症状的重要预测指标（P =？0.020，而T1的血清雌二醇浓度则是抑郁症状的重要指标（P =？0.010）。 T3是焦虑症状，尤其是在T3时间点（P结论围产期中国妇女焦虑和抑郁症状的患病率持续较高。本研究发现RBP对PPD发生的潜在影响，要求为了证实其结果，将来会进行较大规模的随访研究，并进行长期随访。

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