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首页> 外文期刊>BMC Psychiatry >Immune suppression of IgG response against dairy proteins in major depression
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Immune suppression of IgG response against dairy proteins in major depression

机译：免疫抑制严重抑郁症中针对乳蛋白的IgG反应

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Background Interactions between the digestive system, brain functions and immunoglobulin G (IgG) mediated immunity against food antigens became recently a topic of growing interest in psychiatry research. Psychological stress can activate hypothalamic-pituitary-adrenal axis (HPA) with subsequent hypercortisolemia. It can also influence intestinal permeability and dynamics of IgG response. Major depression can by accompanied either by activation of inflammatory response or by immune suppression (e.g. decreased antibody production) where hypercortisolemia is a significant immune modulator. The aim of our study was to assess IgG immune response against 44 food products in depressed patients and controls along with markers of psychological stress, inflammation, psychometric and dietary parameters. Methods Serum IgG concentrations against 44 food antigens, plasma cortisol, TNF-α, IL-6, IL-1b concentrations were measured and psychometric parameters were evaluated using Hamilton Depression Rating (HAM-D 17), Perceived Stress (PSS-10), and Symptom Checklist (SCL-90) scales in 34 depressed patients and 29 controls. Dietary parameters such as frequency of exposure to food antigens, appetite and weight change were assessed. Results There was a significantly lower IgG concentration against dairy in depressed patients compared to controls (post hoc p p =?0.025, η2?=?0.12). There was no significant difference in mean IgG concentration against food antigens between patients and controls. We found increased concentration of cortisol in depressed patients (t (1.61)?=?2.37, p =?0.02) compared to controls. Patients with melancholic depression had significantly higher ( M rank ?=?21.27) concentration of cortisol ( U =?41, p =?0.006), when compared with the non-melancholic group of patients ( M rank ?=?12.16). Cortisol concentration significantly positively correlated with HAM-D 17 ( r =?0.442, p =?0.009) and with phobias in SCL-90 scale in patients’ group ( r =?0.531, p =?0.001). There was decreased concentration of TNF-α ( t =?4.256, p Conclusions We observed an immune suppression of IgG response to dairy proteins in depressed patients. Hypercortisolemia with involvement of decreased concentration of TNF-α might play a significant role in suppression of IgG response in depressed patients.
机译：背景技术消化系统，脑功能和免疫球蛋白G（IgG）介导的针对食物抗原的免疫之间的相互作用最近已成为精神病学研究中日益引起关注的话题。心理压力会激活下丘脑-垂体-肾上腺轴（HPA），继而引起高皮质醇血症。它还可以影响肠道通透性和IgG反应的动力学。重度抑郁症可伴有炎症反应的激活或免疫抑制（例如抗体生成减少），其中高皮质醇血症是重要的免疫调节剂。我们研究的目的是评估抑郁症患者和对照者针对44种食品的IgG免疫反应，以及心理压力，炎症，心理和饮食参数的标志。方法测量针对44种食物抗原的血清IgG浓度，血浆皮质醇，TNF-α，IL-6，IL-1b的浓度，并使用汉密尔顿抑郁评估（HAM-D 17），感知压力（PSS-10）评估心理参数。和症状清单（SCL-90）在34例抑郁症患者和29例对照中进行了测量。评估饮食参数，例如食物抗原的暴露频率，食欲和体重变化。结果与对照组相比，抑郁症患者的抗乳制品IgG浓度显着降低（事后p p =？0.025，η 2 ？=？0.12）。患者和对照之间针对食物抗原的平均IgG浓度无显着差异。与对照组相比，我们发现抑郁症患者的皮质醇浓度升高（t（1.61）？=？2.37，p =？0.02）。与非忧郁症患者相比，忧郁症抑郁患者的皮质醇浓度（M = <21.41）显着更高（M = <21.41，p = 0.006）。 sub> rank ？=？12.16）。患者组中皮质醇浓度与HAM-D 17（r =？0.442，p =？0.009）和恐惧症呈显着正相关（r =？0.531，p =？0.001）。结论观察到抑郁症患者对乳蛋白的IgG免疫抑制有免疫抑制作用，高皮质醇血症伴TNF-α浓度降低可能对IgG的抑制起重要作用。抑郁症患者的反应。

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