• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>BMC Psychiatry >Differential mitochondrial DNA copy number in three mood states of bipolar disorder
【24h】

Differential mitochondrial DNA copy number in three mood states of bipolar disorder

机译：双相情感障碍三种情绪状态下的线粒体DNA差异拷贝数

获取原文
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Accumulating evidences indicated that mitochondrial abnormalities were associated with bipolar disorder. As a sensitive index of mitochondrial function and biogenesis, Mitochondrial DNA copy number (mtDNAcn) may be involved in the pathophysiology of bipolar disorder. Leukocyte relative mtDNAcn was measured by quantitative polymerase chain reaction in subjects with BD (n?=?131) in manic, depressive, and euthymic symptoms. Thirty-four healthy individuals were used as comparison control. BD clinical symptomatology was evaluated by Young Mania Rating Scale (YMRS), Hamilton Depression Scale (HAM-D), Clinical Global Impression-Bipolar Disorder-Severity of Illness Scale (CGI-BD-S), and the Positive and Negative Syndrome Scale (PANSS). Compared to healthy controls, BD patients with manic and depressive symptoms presented significantly decreased mtDNAcn levels (p-value?=?0.009 and 0.041, respectively). No significant differences were detected in mtDNAcn between euthymic patients and healthy controls. The mtDNAcn was negatively correlated with the number of relapses in manic patients (β?=???0.341, p?=?0.044). Our study described the first evidence of (1) a significant decline of mtDNAcn in manic BD patients, (2) a similar decreased level of mtDNAcn between manic and depressed BD patients, (3) a negative correlation of mtDNAcn with number of relapses in patients suffering from manic states. Alterations of mtDNAcn in manic and depressed patients, which may reflect disturbances of energy metabolism, supported the role of mitochondrial abnormalities in the pathophysiology of BD.
机译：越来越多的证据表明线粒体异常与躁郁症有关。作为线粒体功能和生物发生的敏感指标，线粒体DNA拷贝数（mtDNAcn）可能参与了躁郁症的病理生理。通过定量聚合酶链反应，对躁狂，抑郁和正常人症状的BD（n？=？131）受试者进行白细胞相对mtDNAcn测定。 34名健康个体用作对照。 BD临床症状由年轻躁狂评分量表（YMRS），汉密尔顿抑郁量表（HAM-D），临床总体印象-双相情感障碍-疾病严重程度量表（CGI-BD-S）和阳性和阴性综合征量表（ PANSS）。与健康对照相比，患有躁狂和抑郁症状的BD患者的mtDNAcn水平显着降低（p值分别为0.009和0.041）。在正常患者和健康对照之间的mtDNAcn中未检测到显着差异。 mtDNAcn与躁狂患者的复发次数呈负相关（β= 0.341，p = 0.044）。我们的研究描述了以下第一个证据：（1）躁狂性BD患者的mtDNAcn显着下降;（2）躁狂和抑郁的BD患者之间的mtDNAcn降低水平相似;（3）mtDNAcn与患者复发次数呈负相关患有躁狂状态。躁狂和抑郁患者的mtDNAcn改变可能反映了能量代谢紊乱，支持了线粒体异常在BD病理生理中的作用。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号