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首页> 外文期刊>BMC Psychiatry >Brain structural and functional dissociated patterns in schizophrenia
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Brain structural and functional dissociated patterns in schizophrenia

机译：精神分裂症的大脑结构和功能分离模式

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Background Although previous studies found that aberrations in gray matter volume (GMV) and global functional connectivity density (gFCD) are important characteristics of schizophrenia, to the best of our knowledge no study to date has investigated the associations between the spatial distribution patterns of GMV and gFCD alterations. We investigated pattern changes in gFCD and GMV among patients with schizophrenia and their associated spatial distributions. Methods Ninety-five patients with schizophrenia and 93 matched healthy controls underwent structural and resting-state functional MRI scanning to assess gFCD and GMV. Results We found that gFCD increased in the subcortical regions (caudate, pallidum, putamen, and thalami) and limbic system (left hippocampus and parahippocampus), and decreased in the posterior parieto-occipito-temporal cortices (postcentral gyri, occipital cortex, temporo-occipital conjunction, and inferior parietal lobule), in patients with schizophrenia. By contrast, we found decreased GMV in brain regions including the frontal, parietal, temporal, occipital, cingulate cortices, and the insular, striatum, thalamus in these patients. Increased gFCD primarily occurred in subcortical regions including the basal ganglia and some regions of the limbic system. Decreased gFCD appeared primarily in the cortical regions. There were no statistically significant correlations between changes in gFCD and GMV, and their spatial distribution patterns, in different regions. Conclusions Our findings indicate that gFCD and GMV are both perturbed in multiple brain regions in schizophrenia. gFCD and GMV consistently decreased in the cortical regions, with the exception of the Supplementary Motor Area (SMA). However, in the sub-cortical regions, the alterations of gFCD and GMV showed the opposite pattern, with increased gFCD and decreased GMV simultaneously observed in these regions. Overall, our findings suggest that structural and functional alterations appear to contribute independently to the neurobiology of schizophrenia.
机译：背景技术尽管先前的研究发现，灰质体积（GMV）和总体功能连接密度（gFCD）的畸变是精神分裂症的重要特征，但据我们所知，迄今为止，尚无研究调查GMV和疾病的空间分布模式之间的关联。 gFCD更改。我们调查了精神分裂症患者中gFCD和GMV的模式变化及其相关的空间分布。方法对95例精神分裂症患者和93例健康对照者进行结构和静息状态MRI扫描，以评估gFCD和GMV。结果我们发现，gFCD在皮质下区域（尾状，苍白球，壳状核和丘脑）和边缘系统（左海马和海马旁）增加，而在后顶顶枕颞颞皮层（中央后回，枕叶皮质，颞颞叶）减少精神分裂症患者的枕骨顶叶和顶叶下叶）。相比之下，我们发现这些患者的大脑区域，包括额叶，顶叶，颞叶，枕叶，扣带回皮质和岛状，纹状体，丘脑的GMV降低。 gFCD升高主要发生在皮质下区域，包括基底神经节和边缘系统的某些区域。 gFCD减少主要出现在皮质区域。在不同地区，gFCD和GMV的变化与其空间分布模式之间没有统计学上的显着相关性。结论我们的发现表明，gFCD和GMV都在精神分裂症的多个大脑区域受到干扰。除补充运动区（SMA）外，皮质区域的gFCD和GMV持续下降。然而，在皮质下区域，gFCD和GMV的变化显示出相反的模式，在这些区域中同时观察到gFCD升高和GMV降低。总的来说，我们的发现表明结构和功能的改变似乎独立于精神分裂症的神经生物学。

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