...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Brazilian Journal of Otorhinolaryngology >Predictive factors of occult neck metastasis in patients with oral squamous cell carcinoma a??
【24h】

Predictive factors of occult neck metastasis in patients with oral squamous cell carcinoma a??

机译：口腔鳞癌患者隐匿性颈部转移的预测因素

获取原文
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

INTRODUCTION: It is well established that cervical lymph node metastasis is the most important prognostic factor in patients with oral squamous cell carcinoma of the upper aerodigestive tract. The definition of parameters and classifications that could separate patients in groups of low, intermediate and high-risk is being attempted for several years. OBJECTIVE: The objective of this study was to determine possible predictive factors related to the occurrence of occult cervical lymph node metastasis through the analysis of histopathological reports of surgical specimens obtained after oral squamous cell carcinoma resection and selective neck dissections of patients initially classified as N0. METHODS: This was a primary, retrospective, observational, case-control study. Histopathological reports were reviewed to determine if some findings were related to the occurrence of occult lymph node metastasis. The events analyzed were oral cavity subsites, pT-stage, muscular infiltration, desmoplasia, vascular emboli, perineural infiltration, tumor thickness and compromised margins. RESULTS: Occult cervical metastasis accounted for 19.10 percent of the cases. Desmoplasia, perineural infiltration, tumor thickness and pT4a stage are predictive factors of occult neck metastasis ( p -value = 0.0488, 0.0326, 0.0395, 0.0488, respectively). CONCLUSION: The accurate definition of predictive factors of occult cervical metastasis may guide the selection of patients that should be referred to radiotherapy, avoiding the unnecessary exposure of low-risk patients to radiation and allowing a better regional control of the disease in those of moderate or high risk.
机译：引言众所周知，宫颈淋巴结转移是上消化道口腔鳞状细胞癌患者最重要的预后因素。试图将可能将患者分为低，中和高风险组的参数和分类的定义已经尝试了几年。目的：本研究的目的是通过分析口腔鳞状细胞癌切除和选择性颈淋巴结清扫术（最初分类为N0）后获得的手术标本的组织病理学报告，确定与隐匿性颈淋巴结转移发生有关的可能预测因素。方法：这是一项主要的回顾性观察性病例对照研究。回顾了组织病理学报告，以确定某些发现是否与隐匿性淋巴结转移的发生有关。分析的事件是口腔亚位点，pT期，肌肉浸润，增生，血管栓塞，神经周围浸润，肿瘤厚度和切缘受损。结果：隐匿性宫颈转移占病例的19.10％。增生，神经周围浸润，肿瘤厚度和pT4a分期是隐匿性颈部转移的预测因素（p值分别为0.0488、0.0326、0.0395、0.0488）。结论：隐匿性宫颈转移的预测因素的准确定义可以指导应选择放射治疗的患者的选择，避免低危患者不必要地接受放射线照射，并可以更好地区域控制中度或中等水平的患者高风险。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号