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首页> 外文期刊>Brazilian Journal of Otorhinolaryngology >Wound healing in the jugal mucosa of rats with a cold blade scalpel and an ultrasonic harmonic scalpel
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Wound healing in the jugal mucosa of rats with a cold blade scalpel and an ultrasonic harmonic scalpel

机译：冷刀手术刀和超声谐波手术刀在大鼠口腔黏膜的伤口愈合

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摘要

Ultrasound harmonic scalpel has been recently introduced in otorhinolaryngological procedures. AIM: to assess macro and microscopic evolution of the healing process of wounds created in the jugal mucosa of rats by the use of ultrasound scalpel. METHOD: we used 30 Wistar rats in which we made mucosal incisions on the right jugal mucosa with the ultrasound harmonic scalpel (USHS) and on the left side with the cold blade scalpel (CBS). Macroscopic and microscopic evaluations were carried out on the third, seventh and fourteenth days of postoperative. For the microscopic evaluation we used HE to asses the inflammatory process and the Sirius Red approach for collagens type I and III. Anti-CD 3 antibodies and anti-factor VIII assessed the concentration of T-lymphocytes and neovessels. RESULTS: the USHS caused greater cell damage with reepitelization delay. Microscopy showed more intense inflammatory reactions and a loss in collagen build up, delay in scar maturation and a greater vessel neoformation. CONCLUSION: USHS brings about a greater lesion in the incision area; delayed regeneration; promotes greater inflammatory process and angiogenic activity; delays in fibroplasia and scar tissue maturation on the rats' jugal mucosa when compared to cold blade scalpel.
机译：最近在耳鼻喉科手术中引入了超声谐波手术刀。目的：通过超声解剖刀评估在大鼠的口腔粘膜上形成的伤口愈合过程的宏观和微观演变。方法：我们使用了30只Wistar大鼠，在其中用超声谐波解剖刀（USHS）在右乳腺粘膜上切开粘膜切口，并在冷刀片解剖刀（CBS）上在左侧切开粘膜切口。术后第三天，第七天和第十四天进行宏观和微观评估。对于显微镜评估，我们使用HE评估了I型和III型胶原的炎症过程和Sirius Red方法。抗CD 3抗体和抗VIII因子评估了T淋巴细胞和新血管的浓度。结果：USHS造成了更大的细胞损伤，并引起了再延髓。显微镜显示出更强烈的炎症反应和胶原蛋白的积累损失，疤痕成熟的延迟和更大的血管新生。结论：USHS在切口区域造成更大的病灶。延迟再生;促进更大的炎症过程和血管生成活性;与冷刀手术刀相比，可延缓大鼠法律黏膜上皮组织的增生和疤痕组织的成熟。

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