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首页> 外文期刊>Brain and Behavior >Disruption of sleep architecture in Prevotella enterotype of patients with obstructive sleep apnea‐hypopnea syndrome
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Disruption of sleep architecture in Prevotella enterotype of patients with obstructive sleep apnea‐hypopnea syndrome

机译：阻塞性睡眠呼吸暂停低通气综合征患者普氏杆菌肠型的睡眠结构破坏

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Introduction Intermittent hypoxia and sleep fragmentation are critical pathophysiological processes involved in obstructive sleep apnea‐hypopnea syndrome (OSAHS). Those manifestations independently affect similar brain regions and contribute to OSAHS‐related comorbidities that are known to be related to the host gut alteration microbiota. We hypothesized that gut microbiota disruption may cross talk the brain function via the microbiota–gut–brain axis. Thus, we aim to survey enterotypes and polysomnographic data of patients with OSAHS. Methods Subjects were diagnosed by polysomnography, from whom fecal samples were obtained and analyzed for the microbiome composition by variable regions 3–4 of 16S rRNA pyrosequencing and bioinformatic analyses. We examined the fasting levels of interleukin‐6 and tumor necrosis factor‐alpha of all subjects. Results Three enterotypes Bacteroides , Ruminococcus , and Prevotella were identified in patients with OSAHS. Arousal‐related parameters or sleep stages are significantly disrupted in apnea‐hypopnea index (AHI) ≥15 patients with Prevotella enterotype; further analysis this enterotype subjects, obstructive, central, and mixed apnea indices, and mean heart rate are also significantly elevated in AHI ≥15 patients. However, blood cytokines levels of all subjects were not significantly different. Conclusions This study indicates the possibility of pathophysiological interplay between enterotypes and sleeps structure disruption in sleep apnea through a microbiota–gut–brain axis and offers some new insight toward the pathogenesis of OSAHS.
机译：简介间歇性缺氧和睡眠破碎是阻塞性睡眠呼吸暂停低通气综合征（OSAHS）的关键病理生理过程。这些表现独立影响相似的大脑区域，并导致与OSAHS相关的合并症，已知与宿主肠道改变菌群相关。我们假设肠道微生物群的破坏可能会通过微生物群-肠-脑轴交叉串扰大脑功能。因此，我们旨在调查OSAHS患者的肠型和多导睡眠图数据。方法通过多导睡眠监测仪对受试者进行诊断，从中获取粪便样品，并通过16S rRNA焦磷酸测序的3–4个可变区和生物信息学分析来分析微生物组组成。我们检查了所有受试者的白介素-6和肿瘤坏死因子-α的禁食水平。结果在OSAHS患者中鉴定出了三种肠杆菌，肠球菌和小肠杆菌。呼吸暂停低通气指数（AHI）≥15的普氏杆菌肠型患者的与耳有关的参数或睡眠阶段受到严重破坏;进一步分析，在AHI≥15的患者中，该肠型受试者，阻塞性，中枢性和混合性呼吸暂停指数以及平均心率也显着升高。但是，所有受试者的血细胞因子水平均无显着差异。结论这项研究表明，通过微生物-肠-脑轴在睡眠呼吸暂停中，肠型和睡眠结构破坏之间可能存在病理生理相互作用，并为OSAHS的发病机理提供了一些新见解。

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