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Parenteral Nutrition in Patients with Advanced Cancer and Gastrointestinal Failure or Obstruction

机译：晚期癌症和胃肠道衰竭或阻塞患者的肠胃外营养

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Malnutrition in patients with advanced cancer and gastrointestinal failure (ACGIF) is inevitable. This is a prospective study of a cohort of patients with ACGIF who were treated by home parenteral nutrition (HPN).Included were all patients with ACGIF treated with HPN since January 2003. Data concerning the primary disease, demographics, functional capacity, and PN-related complications were obtained.125 patients, age's 60±12.9 years, were included. Seven (6%) had KPS50. Median survival was 3.2 months. Cumulative survivalwas 0.95, 0.50, 0.25, and 0.09 at two weeks, three and six months, and one year after initiation of HPN, respectively. Multivariate analysis revealed higher mortality associated with male gender (HR 1.48 95% CI 1.03-2.14; p0.05), albumin level2.5 gr% (HR 1.73 95% CI 1.18-2.54 p0.05), and low functional capacity (KPS50) (HR 2.63 95% CI 1.21-5.74; p0.05). Survival was not associated with age or BMI.More than 50% of patients survived more than three months, and more than 95% survived longer than two weeks. We cautiously suggest that HPN has prolonged survival and prevented starvation-related manifestations. The decision to initiate HTPN must be reached based on individual considerations, taking into account patient’s preferences.??.
机译：晚期癌症和胃肠道衰竭（ACGIF）患者营养不良是不可避免的。这是一项对接受家庭肠胃外营养（HPN）治疗的ACGIF患者队列的前瞻性研究。包括自2003年1月以来所有接受HPN治疗的ACGIF患者。有关原发疾病，人口统计学，功能能力和PN-获得了相关的并发症。纳入患者125例，年龄60±12.9岁。七（6％）的KPS <50。中位生存期为3.2个月。 HPN发生后两周，三个月和六个月以及一年的累积生存率分别为0.95、0.50、0.25和0.09。多变量分析显示与男性相关的死亡率较高（HR 1.48 95％CI 1.03-2.14; p <0.05），白蛋白水平<2.5 gr％（HR 1.73 95％CI 1.18-2.54 p <0.05）和低功能能力（KPS） <50）（HR 2.63 95％CI 1.21-5.74; p <0.05）。存活率与年龄或BMI无关.50％以上的患者存活超过三个月，而95％以上的患者存活超过两周。我们谨慎地建议HPN可以延长生存期并预防饥饿相关的表现。启动HTPN的决定必须基于个人的考虑，并考虑患者的喜好。

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