• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Cancer and Clinical Oncology >Brain Tumor Treatment: 2017 Update
【24h】

Brain Tumor Treatment: 2017 Update

机译：脑肿瘤治疗：2017年更新

获取原文
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Malignant brain tumors are a heterogeneous group of diseases arising from different cell types that affect both adults and children. The high recurrence rate of malignant brain tumors typically is due to reappearance of focal masses, indicating that a sub population of tumor cells are insensitive to current therapies and may be responsible for reinitiating tumor growth. It is generally agreed that the resistant tumor cells are comprised of cancer stem cells or tumor-initiating cells. While brain tumor stem cells (BTSCs) were first isolated within the last decade, much of the early research has been focused on identifying the BTSC markers and therapeutic targets. The challenge however, is to translate this knowledge to therapeutics. In the current review, we survey the remedial strategies to target BTSCs, which includes diagnostic, pharmacologic, immunologic, viral, and post-transcriptional approaches.
机译：恶性脑肿瘤是异种疾病，由不同类型的细胞引起，影响成年人和儿童。恶性脑肿瘤的高复发率通常归因于局灶性肿块的出现，这表明肿瘤细胞亚群对当前的治疗方法不敏感，可能导致肿瘤重新开始生长。通常同意，抗性肿瘤细胞由癌症干细胞或肿瘤起始细胞组成。尽管脑肿瘤干细胞（BTSC）在过去十年中首次分离出来，但许多早期研究都集中在鉴定BTSC标志物和治疗靶标上。然而，挑战在于将这种知识转化为治疗方法。在当前的审查中，我们调查针对BTSC的补救策略，包括诊断，药理，免疫，病毒和转录后方法。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号