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首页> 外文期刊>Bulletin of Clinical Psychopharmacology >Parasuicidal patients in the emergency department and their relationship with cannabinoid gene polymorphism
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Parasuicidal patients in the emergency department and their relationship with cannabinoid gene polymorphism

机译：急诊室的自杀超人患者及其与大麻素基因多态性的关系

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Background: Suicidal behavior represents a serious public health problem. Studies about twins, adoption, and family con?icts have shown a relationship between genetics and suicide. CB1 receptors are coded by the cannabinoid-1 receptor (CNR1) gene. It has been shown that CNR1 gene polymorphism (1359 G/A) is associated with many neuropsychiatric disorders, including major depression. Objective: Our aim was to study whether there was an association between the polymorphism of the CNB1 receptor and suicide attempts. We compared non-suicidal subjects with suicide-attempt victims to substantiate these findings. Materials and Methods: Peripheral blood samples were drawn from all of the participants and single nucleotide polymorphism (SNP) of the cannabinoid gene (1359 G/A) was analyzed. Results: The study included 115 suicide attempts (parasuicide patients) (mean age 25.6±8.5; 41 males, 74 females) and 69 unrelated healthy subjects (mean age 27.5±10.6; 38 males, 31 females). The genotype distributions were significantly different between the parasuicide and control groups and this difference was attributed to the AG genotype rates (21.7% vs 44.9%, p=0.001). Having the AG genotype lowered the admission to the ED due to parasuicide 3.3 times (95% CI: 1.6-6.8). The frequencies of A and G alleles in the CNR1 gene polymorphism were 16.1% (n=37) and 83.9% (n=193) in parasuicide patients and 22.5% (n=31) and 77.5% (n=107) in the control group, respectively (p=0.127). All the subjects with the AA genotype were in the parasuicide group (n=6). The frequency of the AG genotype was significantly lower in parasuicide patients with a previous psychiatric diagnosis compared to suicide attempts without a previous diagnosis (32% (n=8) vs. 68% (n=17); p=0.004). Conclusion: There is a preventive association between CNR1 rs1049353 (1359 G/A) gene polymorphism and parasuicide patients. CNR1 receptor polymorphism may be used as a biological test to help predict and prevent suicidal behavior if the relationship can be proved with further studies.
机译：背景：自杀行为代表严重的公共卫生问题。关于双胞胎，收养和家庭冲突的研究表明，遗传与自杀之间存在联系。 CB1受体由大麻素1受体（CNR1）基因编码。已经显示CNR1基因多态性（1359 G / A）与许多神经精神疾病有关，包括重度抑郁。目的：我们的目的是研究CNB1受体的多态性与自杀未遂之间是否存在关联。我们将非自杀受试者与自杀倾向受害者进行比较，以证实这些发现。材料与方法：从所有参与者中抽取外周血样本，并分析大麻素基因（1359 G / A）的单核苷酸多态性（SNP）。结果：该研究包括115例自杀未遂（超自杀患者）（平均年龄25.6±8.5;男性41例，女性74名）和69位无关的健康受试者（平均27.5±10.6岁;男性38例女性31）。在副自杀组和对照组之间，基因型分布存在显着差异，这种差异归因于AG基因型发生率（21.7％对44.9％，p = 0.001）。具有AG基因型会降低3.3倍的自杀率（95％CI：1.6-6.8），从而降低了ED的入院率。自杀患者中CNR1基因多态性的A和G等位基因频率分别为16.1％（n = 37）和83.9％（n = 193），对照组为22.5％（n = 31）和77.5％（n = 107）组分别（p = 0.127）。所有具有AA基因型的受试者均处于副自杀组（n = 6）。与没有事先诊断的自杀尝试相比，先前有精神病诊断的副自杀患者的AG基因型频率显着降低（32％（n = 8）对68％（n = 17）; p = 0.004）。结论：CNR1 rs1049353（1359 G / A）基因多态性与副自杀患者之间存在预防关联。如果可以通过进一步研究证明这种关系，CNR1受体多态性可以用作生物学测试，以帮助预测和预防自杀行为。

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