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首页> 外文期刊>Balkan journal of medical genetics: BJMG >An investigation of the COMT gene Val158Met polymorphism in patients admitted to the emergency department because of synthetic cannabinoid use
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An investigation of the COMT gene Val158Met polymorphism in patients admitted to the emergency department because of synthetic cannabinoid use

机译：用合成大麻素使用患者患者患者COMT基因Val158met多态性的研究

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Catechol-O-methyl transferase (COMT) enzyme has a role in the inactivation of catecholamine neurotransmitters. Functional polymorphism in the COMT gene has been reported to play an important role in schizophrenia, bipolar affective disorder, aggressive and antisocial behavior, suicide attempts and the pathogenesis of Parkinsona??s disease. In this study, we aimed to investigate the effect of the Vall58Met polymorphism of the COMT gene on substance use, and treatment history in patients with synthetic cannabinoid (SC) intoxication. The COMT enzyme Val158Met polymorphisms from DNA of 49 patients who were evaluated in the Emergency Department after SC use and 50 healthy control groups aged 18-45 years, were identified by polymerase chain reaction (PCR) and restriction fragment length polymorphism (RFLP) analyses as reported in the literature. Information regarding recurrent intake or hospitalization due to substance use was obtained from hospital records. Wild-type (WT) genotypes in 14 (28.6%) patients, heterozygous genotypes in 25 (51.0%) and homozygous genotypes in 10 (20.4%) patients were detected. Wild-type genotypes The homozygous genotype was found to be significantly higher in patients hospitalized due to drug addiction and substance use (p 0.008). The Vall58 Met polymorphism of the COMT gene was not found to be significant in the first use after substance intake, while a significant relationship was found in terms of this polymorphism in patients with substance addiction diagnosis and treatment history.
机译：儿茶酚-O-甲基转移酶（COMT）酶在服用灭活的儿茶酚胺神经递质中具有作用。据报道，COMT基因中的功能多态性在精神分裂症中发挥着重要作用，双相情感障碍，侵略性和反社会行为，自杀企图和帕金森病的发病机制。在这项研究中，我们旨在探讨COMT基因Vall58met多态性对物质使用的影响，以及合成大麻毒素（SC）中毒患者的治疗史。通过聚合酶链反应（PCR）和限制片段长度多态性（RFLP）分析，鉴定来自在SC使用后在急诊部门评估的49名患者中评估的49名患者的DNA多态性和18-45岁的健康对照组。在文献中报道。从医院记录中获得有关物质的反复摄入或住院的信息。 14例（28.6％）患者的野生型（WT）基因型，杂合子基因型在25（51.0％）和10例（20.4％）患者中的纯合基因型中的杂合基因型。野生型基因型纯合基因型被发现由于药物成瘾和物质使用而住院的患者显着更高（p 0.008）。 Vall58在物质摄入后的第一次使用中没有发现COMT基因的多态性，而在物质成瘾诊断和治疗历史中的这种多态性方面发现了显着的关系。

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