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首页> 外文期刊>Canadian Journal of Pure and Applied Sciences >BIOACTIVE CONSTITUENTS, ACUTE AND SUB-ACUTE EFFECT OF TELFAIRIA OCCIDENTALIS HOOK F (FLUTED PUMPKIN) LEAVES EXTRACT ON SOME KIDNEY FUNCTION INDICES IN RAT
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BIOACTIVE CONSTITUENTS, ACUTE AND SUB-ACUTE EFFECT OF TELFAIRIA OCCIDENTALIS HOOK F (FLUTED PUMPKIN) LEAVES EXTRACT ON SOME KIDNEY FUNCTION INDICES IN RAT

机译：西番莲钩子F（全南瓜）叶的生物活性成分，急性和次急性作用对大鼠某些肾脏功能指标的提取

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This study assessed the renal toxicity potentials of Telfairia occidentalis Hook f, a widely consumed vegetable in Nigeria and other parts of the world. Fifty healthy adult Wistar albino rats were randomly selected and divided into two groups A and B. Each group was divided into 5 sub-groups: 1, 2, 3, 4 and 5. Subgroup 1 served as the control group and was fed with standard animal feed only, while sub-groups 2, 3, 4 and 5 were test groups, and in addition to the standard animal feed, 500mg/kg, 1000mg/kg, 2000mg/kg and 4000mg/kg extract of Telfairia occidentalis leaves was orally gavaged to the test groups 2, 3, 4 and 5 respectively. Animals in group A were tested for acute effect after 10 days of extract administration. Those in group B were similarly assessed for sub-acute effect after 4 weeks of extract administration. Acute phase of extract administration produced significant increases only in K + and urea levels at P < 0.05 and P < 0.01 respectively. In the sub-acute phase, significant increases in total body weight (P < 0.01), kidney weight (P < 0.01), kidney to body weight ratio (P < 0.001), K + (P < 0.001), HCO -3 (P < 0.01) and urea (P < 0.01) were obtained. The effect of the extract on renal function indices may be dose-dependent, hence dosage adjustment may be necessary in patients with renal impairment.
机译：这项研究评估了尼日利亚和世界其他地区广泛食用的蔬菜西洋蓟（Telfairia occidentalis Hook f）的肾毒性潜力。随机选择五十只健康的成年Wistar白化病大鼠，分为A组和B组。每组分为5个亚组：1、2、3、4和5。亚组1为对照组，并喂以标准饲料。仅动物饲料，而第2、3、4和5组为测试组，除标准动物饲料外，还口服口服500mg / kg，1000mg / kg，2000mg / kg和4000mg / kg的西洋榄叶提取物分别进入测试组2、3、4和5。给予提取物10天后，对A组动物的急性作用进行了测试。提取物给药4周后，对B组的亚急性效果进行了类似的评估。分别在P <0.05和P <0.01时，施用提取物的急性期仅使K +和尿素水平显着增加。在亚急性期，总体重（P <0.01），肾脏重量（P <0.01），肾脏与体重之比（P <0.001），K +（P <0.001），HCO -3（获得P <0.01）和尿素（P <0.01）。提取物对肾功能指标的影响可能是剂量依赖性的，因此对于肾功能不全的患者可能需要调整剂量。

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