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首页> 外文期刊>Canadian Journal of Pure and Applied Sciences >Inhibitory Effect of the Medicinal Plant, Eclipta alba Linn. on Skin Carcinogenesis in Swiss Albino Mice
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Inhibitory Effect of the Medicinal Plant, Eclipta alba Linn. on Skin Carcinogenesis in Swiss Albino Mice

机译：药用植物Eclipta alba Linn的抑制作用。白化小鼠皮肤致癌作用的研究

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摘要

Chemoprevention using readily accessible natural substances from vegetables, fruits, herbs and spices is presently considered as one of the most noteworthy strategies for cancer prevention. The herb, Eclipta alba Linn (Family: Compositae) found commonly in moist places all over India is traditionally used as a tonic and deobstruent in hepatic and spleen enlargements .It has also got anti- inflammatory effect and may be applied to insect bites, stings, swellings and other skin diseases. The present investigation was undertaken to explore the anti tumor promoting activity of Eclipta alba on two stage skin carcinogenesis, induced by a single topical application of 7, 12 Dimethyl benz (a) anthracene (50μg/ 50μl of acetone) and two weeks later, promoted by repeated application of croton oil (1% in acetone for 3 times a week) till the end of the experiment (15 weeks). Topical application of the hydro alcoholic extract of the herb, Eclipta alba for 15 weeks at the pre, peri and post initiational stages on the shaven backs of Swiss albino mice was found to be effective in decreasing the tumor incidence (90, 77.77 and 66.6% respectively) in comparison to the control (100%). The cumulative number of papillomas, tumor yield and tumor burden were also found to be reduced significantly in E. alba treated mice. The histo-pathology of the affected skin tissue also indicated a significant reduction in the tumor size and slow growth of the tumors in the treated groups in comparison to the control. The results thus suggest a possible chemopreventive property of E. alba against DMBA induced skin papillomagenesis.
机译：使用蔬菜，水果，药草和香料中容易获得的天然物质进行化学预防，目前被认为是预防癌症最值得注意的策略之一。传统上在印度潮湿的地方普遍发现的草本植物Eclipta alba Linn（家族：菊科）在肝脏和脾脏肿大时用作滋补剂和去味剂，还具有抗炎作用，可用于昆虫叮咬，s ，肿胀和其他皮肤疾病。进行本研究以探讨白纹东邪对两阶段皮肤癌变的抗肿瘤促进活性，该促进作用是通过一次局部应用7、12二甲基苯并（a）蒽（50μg/50μl丙酮）和两周后促进的。通过重复施用巴豆油（1％的丙酮溶液，每周3次）直至实验结束（15周）。在瑞士白化病小鼠的剃毛后背上，在初始，周围和后阶段局部施用草药水草提取物15周，可有效降低肿瘤发生率（90、77.77和66.6％）相较于对照（100％）。还发现在经大肠杆菌处理的小鼠中，乳头状瘤的累积数目，肿瘤产量和肿瘤负荷显着降低。与对照组相比，受治疗的皮肤组织的组织病理学还表明，在治疗组中，肿瘤的大小显着减小并且肿瘤的生长缓慢。因此，结果表明白大肠埃希氏菌可能对DMBA诱导的皮肤乳头状瘤发生具有化学预防作用。

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