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首页> 外文期刊>Canadian Journal of Pure and Applied Sciences >ASSESSING INDUCED EFFECT OF CURCUMIN ON METHIMAZOLE HEPATIC DAMAGE IN ALBINO RATS: A HISTOLOGICAL AND HISTOCHEMICAL STUDY
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ASSESSING INDUCED EFFECT OF CURCUMIN ON METHIMAZOLE HEPATIC DAMAGE IN ALBINO RATS: A HISTOLOGICAL AND HISTOCHEMICAL STUDY

机译：姜黄素对白化病大鼠甲基咪唑肝损伤的评估诱导效应：组织学和组织化学研究

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The present study investigates the possible protective effect of curcumin on Methimazole (MMZ). It is an anti-thyroid drug induced hepatotoxicity in albino rats. In this study the rats were randomly divided into four experimental groups; first group was used as control treated with a standard diet. The second group was treated with curcumin at dose of 150 mg/kg body weight. The third group was treated with the MMZ dissolved in drinking water at dose of 60mg/kg body weight. The fourth group was treated with a liquid mixture of MMZ and curcumin. The rats were dissected after 6 weeks of treatment and livers of these animal were collected separately and used for histological and histochemical methods. It was clear form the results obtained that the MMZ caused histological alterations in the liver tissue o f the MMZ treated rats. These changes appeared as congestion of blood vessels, leucocytic infiltrations and cytoplasmic vaculation of the hepatocytes. The histochemical analysis has revealed a reduction in carbohydrates content, total proteins and DNA. The histochemical results o f the same rats treated with MMZ showed an increase in serum level of ALT, AST and ALP. However, the group treated with curcumin sho wed a remarkable improvement in the histological structure of the liver tissue. The results revealed an increase in carbohydrates level, total proteins and DNA. In addition the Biochemical results of this group sho wed a noticeable decrease in the hepatic enzymes (ALT, AST and ALP). These finding have confirmed that curcumin is an effective agent with special antioxidant properties that prevent and protect the liver from histological and histochemical damages induced by MMZ.
机译：本研究调查了姜黄素对甲基咪唑（MMZ）的可能的保护作用。它是一种抗甲状腺药物在白化病大鼠中引起的肝毒性。在这项研究中，大鼠被随机分为四个实验组。第一组用作标准饮食治疗的对照组。第二组用姜黄素治疗，剂量为150 mg / kg体重。第三组用溶于饮用水的MMZ进行治疗，剂量为60mg / kg体重。第四组用MMZ和姜黄素的液体混合物治疗。处理6周后将大鼠解剖，并分别收集这些动物的肝脏并用于组织学和组织化学方法。从获得的结果可以清楚地看出，MMZ引起了MMZ治疗的大鼠肝组织的组织学改变。这些变化表现为血管充血，白细胞浸润和肝细胞胞浆排空。组织化学分析显示碳水化合物含量，总蛋白质和DNA减少。同一只接受MMZ治疗的大鼠的组织化学结果显示血清ALT，AST和ALP升高。但是，用姜黄素治疗的组应改善肝组织的组织学结构。结果显示碳水化合物水平，总蛋白质和DNA均增加。此外，该组的生化结果显示肝酶（ALT，AST和ALP）明显降低。这些发现已经证实姜黄素是一种具有特殊抗氧化特性的有效药物，可以预防和保护肝脏免受MMZ引起的组织学和组织化学损害。

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