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首页> 外文期刊>Canadian Journal of Pure and Applied Sciences >EFFECT OF MAGNESIUM CHLORIDE AND SODIUM FLUORIDE ON VARIOUS HYDROXYPROLINE FRACTIONS IN RAT KIDNEYS
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EFFECT OF MAGNESIUM CHLORIDE AND SODIUM FLUORIDE ON VARIOUS HYDROXYPROLINE FRACTIONS IN RAT KIDNEYS

机译：氯化镁和氟化钠对大鼠肾脏各种羟脯氨酸成分的影响

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摘要

Magnesium chloride (MgCl 2 ) has been reported to protect against sodium fluoride (NaF) induced toxicity. This study was undertaken to study the effect of MgCl 2 on NaF induced alteration in rat kidney hydroxyproline fractions and collagen. Four groups of rats were studied (each consisting of 4-6 rats) (i) normal rats: (ii) rats injected with MgCl 2 : (iii) rats injected with NaF: (iv) rats injected with MgCl 2 followed by NaF. Results show that MgCl 2 and NaF treatment alone and together caused a significant (p < 0.05) decrease in kidney protein, free, peptide–bound, protein-bound, total hydroxyproline and soluble collagen hydroxyproline. Administration of MgCl 2 before NaF did not restore the altered parameters to normal levels. However administration of MgCl 2 before NaF restored insoluble collagen hydroxyproline which was altered by NaF to near normal levels. Though MgCl 2 has been reported to be protective against the toxic effect of NaF, it has no significant effect on NaF induced changes in kidney hydroxyproline/collagen except insoluble collagen Hyp.
机译：据报道氯化镁（MgCl 2）可以防止氟化钠（NaF）引起的毒性。进行该研究以研究MgCl 2对NaF诱导的大鼠肾脏羟脯氨酸级分和胶原蛋白改变的影响。研究了四组大鼠（每组由4-6只大鼠组成）（i）正常大鼠：（ii）注射了MgCl 2的大鼠：（iii）注射了NaF的大鼠：（iv）注射了MgCl 2然后是NaF的大鼠。结果表明，单独使用MgCl 2和NaF并共同处理可使肾脏蛋白质，游离，肽结合，蛋白质结合，总羟脯氨酸和可溶性胶原羟脯氨酸显着降低（p <0.05）。在NaF之前施用MgCl 2不能将改变的参数恢复到正常水平。然而，在NaF之前施用MgCl 2可以恢复不溶性胶原蛋白羟脯氨酸，后者被NaF改变至接近正常水平。尽管据报道MgCl 2可以抵抗NaF的毒性作用，但是除了不溶性胶原Hyp以外，它对NaF诱导的肾脏羟脯氨酸/胶原蛋白变化没有明显作用。

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