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首页> 外文期刊>Cancer Management and Research >Prognostic significance of a novel indicator (PSA postd3 /PSA pre )?for PSA recurrence in patients after radical prostatectomy
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Prognostic significance of a novel indicator (PSA postd3 /PSA pre )?for PSA recurrence in patients after radical prostatectomy

机译：前列腺癌根治术后新指标（PSA postd3 / PSA pre）对PSA复发的预后意义

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Purpose: Radical prostatectomy (RP) is a common treatment for prostate cancer, but a fraction of patients may experience PSA recurrence after surgery, manifesting as an elevation in prostate specific antigen (PSA). Vast literature has reported different prognostic factors for PSA recurrence without reaching a consensus. This retrospective study investigated the efficacy of a new indicator in predicting PSA recurrence in patients after RP. Patients and methods: From October 2000 to December 2015, 102 PCa patients who underwent laparoscopic prostatectomy in the Urology Department of Peking Union Medical College Hospital were analyzed. We calculated PSAsubpostd3/sub/PSAsubpre/sub, defined as the ratio of the PSA on day 3 postop as the numerator and the pre-operative PSA as the denominator, in these patients to represent PSA decrement after surgery, and investigated its relationship with PSA recurrence during follow-up. Results: The receiver operating characteristic (ROC) curve of PSAsubpostd3/sub/PSAsubpre/sub derived a cut-off at 0.453 (sensitivity=0.704, specificity=0.853, P 0.0001), suggesting an increased risk of PSA recurrence in patients whose PSA on day 3 postop did not decrease to approximately half of their preoperative levels. Among several factors, PSAsubpostd3/sub/PSAsubpre/sub ( P 0.0001), pathological T stage ( P =0.042) and Gleason Grade ( P =0.021) were determined to be significantly associated with PSA recurrence by Fisher’s exact test, while only PSAsubpostd3/sub/PSAsubpre/sub ( P 0.001) was significantly related to PSA recurrence-free survival (PRFS) by multivariate logistic regression analysis. Conclusion: These results imply that PSAsubpostd3/sub/PSAsubpre/sub could provide substantial information for PSA recurrence prediction in patients after RP.
机译：目的：根治性前列腺切除术（RP）是前列腺癌的常见治疗方法，但是一部分患者在手术后可能会发生PSA复发，表现为前列腺特异性抗原（PSA）升高。大量文献报道了PSA复发的不同预后因素，但尚未达成共识。这项回顾性研究调查了一种新指标在预测RP后患者PSA复发中的功效。患者与方法：自2000年10月至2015年12月，对北京协和医院泌尿外科行腹腔镜前列腺切除术的102例PCa患者进行分析。我们计算了这些患者中PSA postd3 / PSA pre 的定义，定义为术后3天的PSA作为分子，术前PSA作为分母的比率。代表术后PSA减少，并调查其与PSA复发之间的关系。结果：PSA postd3 / PSA pre 的接收器工作特性（ROC）曲线在0.453处得出临界值（灵敏度= 0.704，特异性= 0.853，P <0.0001） ，这表明术后3天PSA并未降低到术前水平的一半的患者PSA复发的风险增加。在几个因素中，PSA postd3 / PSA pre （P <0.0001），病理性T分期（P = 0.042）和格里森分级（P = 0.021）被确定为显着通过Fisher精确检验与PSA复发相关，而只有PSA postd3 / PSA pre （P <0.001）与多元Logistic显着相关于PSA无复发生存期（PRFS）回归分析。结论：这些结果表明，PSA postd3 / PSA pre 可以为RP术后患者的PSA复发预测提供重要信息。

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