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An analysis of the inheritance pattern of an adult-onset hearing loss in Border Collie dogs

机译：边境牧羊犬成年听力损失的遗传模式分析

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BackgroundDuring routine diagnostic BAER testing of dogs of various breeds for private owners at the Western College of Veterinary Medicine in Saskatoon, it became evident that some individual dogs developed hearing loss as adults. Although inherited congenital deafness has been widely reported in dogs, this type of deafness had not. FindingsSpecial clinics were set up to screen working Border Collies at herding competitions. To determine the typical age that geriatric deafness might be expected, retired dogs were also recruited. Five of the 10 Border Collies 12?years of age or older had hearing loss (1 bilaterally deaf and 4 had reduced hearing). The adult onset deafness which exhibited in three families, did not usually occur until 5?years of age, too young to be geriatric deafness. This adult onset deafness fits an autosomal dominant pattern of inheritance. Several of these dogs had been BAER tested at younger ages with no sign of deafness. The deaf dogs were not associated with either gender. A survey was developed which was completed by the dog owners, that indicated that the hearing loss was gradual, not sudden. In addition, some family studies were conducted. ConclusionsDogs at 5?years of age were often in the prime of their herding careers and then did not respond appropriately to distant commands. This type of deafness is important to dog owners but is also a potential medical model for some forms of hearing loss in humans. This report also suggests that geriatric hearing loss is common in dogs older than 12?years.
机译：背景技术在萨斯卡通西部兽医学院针对私人犬种的各种犬的常规诊断性BAER测试期间，很明显有些犬成年后会出现听力下降。尽管遗传性先天性耳聋已在犬中得到广泛报道，但这种耳聋却没有。调查结果成立了专门的诊所，在放牧比赛中对正在工作的边境牧羊犬进行筛查。为了确定可能发生老年性耳聋的典型年龄，还招募了退休的狗。在12岁或12岁以上的10只边境牧羊犬中，有5位听力丧失（双耳聋1位，听力下降4位）。在三个家庭中表现出的成年人发病性耳聋通常直到5岁才出现，因为年龄太小而不能成为老年性耳聋。该成年发作性耳聋符合常染色体显性遗传方式。这些狗中有几只在年轻时就经过了BAER测试，没有耳聋的迹象。聋犬与任何性别均不相关。由狗主人完成的一项调查表明，听力损失是逐渐的，而不是突然的。此外，还进行了一些家庭研究。结论5岁以下的狗通常处于牧民职业的黄金时期，因此对远距离的命令没有适当的反应。这种类型的耳聋对养狗者很重要，但是对于人类某些形式的听力损失也是一种潜在的医学模型。该报告还表明，老年听力损失在12岁以上的狗中很常见。

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