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Searching for 'monogenic diabetes' in dogs using a candidate gene approach

机译：使用候选基因方法在狗中寻找“单基因糖尿病”

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BackgroundCanine diabetes is a common endocrine disorder with an estimated breed-related prevalence ranging from 0.005% to 1.5% in pet dogs. Increased prevalence in some breeds suggests that diabetes in dogs is influenced by genetic factors and similarities between canine and human diabetes phenotypes suggest that the same genes might be associated with disease susceptibility in both species. Between 1-5% of human diabetes cases result from mutations in a single gene, including maturity onset diabetes of the adult (MODY) and neonatal diabetes mellitus (NDM). It is not clear whether monogenic forms of diabetes exist within some dog breeds. Identification of forms of canine monogenic diabetes could help to resolve the heterogeneity of the condition and lead to development of breed-specific genetic tests for diabetes susceptibility. ResultsSeventeen dog breeds were screened for single nucleotide polymorphisms (SNPs) in eighteen genes that have been associated with human MODY/NDM. Six SNP associations were found from five genes, with one gene ( ZFP57 ) being associated in two different breeds. ConclusionsSome of the genes that have been associated with susceptibility to MODY and NDM in humans appear to also be associated with canine diabetes, although the limited number of associations identified in this study indicates canine diabetes is a heterogeneous condition and is most likely to be a polygenic trait in most dog breeds.
机译：背景犬糖尿病是一种常见的内分泌疾病，在宠物犬中估计与品种有关的患病率在0.005％至1.5％之间。在某些品种中，患病率升高表明狗​​的糖尿病受到遗传因素的影响，犬和人类糖尿病表型之间的相似性表明，相同的基因可能与这两种物种的疾病易感性有关。 1-5％的人类糖尿​​病病例是由单个基因的突变引起的，包括成人的成年发作糖尿病（MODY）和新生儿糖尿病（NDM）。尚不清楚某些犬种中是否存在糖尿病的单基因形式。犬单基因糖尿病形式的鉴定可以帮助解决疾病的异质性，并导致针对糖尿病易感性的针对特定品种的基因测试的发展。结果筛选了17个犬种中与人类MODY / NDM相关的18个基因中的单核苷酸多态性（SNP）。从五个基因中发现了六个SNP关联，其中一个基因（ZFP57）在两个不同的品种中关联。结论尽管人类中对MODY和NDM易感性相关的一些基因似乎也与犬类糖尿病有关，但在这项研究中确定的关联数量有限，表明犬类糖尿病是一种异质性疾病，最有可能是多基因大多数犬种的特征。

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