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首页> 外文期刊>Canine Genetics and Epidemiology >Genetics and epidemiology of hypothyroidism and symmetrical onychomadesis in the Gordon setter and the English setter
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Genetics and epidemiology of hypothyroidism and symmetrical onychomadesis in the Gordon setter and the English setter

机译：Gordon setter和English setter中甲状腺功能减退症和对称甲癣的遗传学和流行病学

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BackgroundHypothyroidism is one of the most common endocrine disorders, whereas symmetrical onychomadesis is a rare claw disease in the general dog population. The aims of this study were to estimate the prevalence of hypothyroidism and symmetrical onychomadesis in a birth cohort of 291 Gordon setters at eight years of age. Further, to describe the age at diagnosis of hypothyroidism in the 68 Gordon setters and 51 English setters included in the DLA study. Finally, to elucidate potential associations between dog leukocyte antigen (DLA) class II and hypothyroidism and/or symmetrical onychomadesis in the Gordon setter and the English setter. ResultsIn the birth cohort of eight years old Gordon setters, 2.7?% had hypothyroidism and 8.9?% had symmetrical onychomadesis, but only one out of these 291 dogs (0.3?%) had both diseases. Mean age at diagnosis of hypothyroidism for dogs included in the DLA study was 6.4?years (95?% CI: 5.6-7.2?years) in the Gordon setters and 7.7?years (95?% CI: 7.2-8.2?years) in the English setters. The DLA alleles most associated with hypothyroidism in the Gordon setter and English setter were DLA-DQB1*00201 (OR?=?3.6, 95?% CI: 2.1-6.4, p In the Gordon setter, the haplotype DLA-DRB1*01801/DQA1*00101/DQB1*00802 was significantly associated with both symmetrical onychomadesis (OR?=?2.9, 95?% CI: 1.7-5.2, p ConclusionHypothyroidism is a complex disease where DLA genes together with other genes may be involved in the pathogenesis of the disease. In the Gordon setter, one DLA haplotype that was associated with protection against hypothyroidism was also associated with symmetrical onychomadesis. These findings indicate that closely linked genes, instead of or together with the DLA genes themselves, may be associated with hypothyroidism and symmetrical onychomadesis. In a breed where several autoimmune diseases are prevalent all possible associations between DLA genes and actual diseases need to be investigated before DLA is considered used as a tool for marker-assisted selection.
机译：背景甲状腺功能减退症是最常见的内分泌疾病之一，而对称甲癣是普通犬群中罕见的爪病。这项研究的目的是评估八岁时291名戈登出生者的出生队列中的甲状腺功能低下和对称甲癣的患病率。此外，在DLA研究中描述的68个Gordon制定者和51个英语制定者描述甲状腺功能减退症的诊断年龄。最后，为了阐明戈登制定者和英语制定者中狗白细胞抗原（DLA）II类与甲状腺功能减退和/或对称甲癣之间的潜在关联。结果在八岁的戈登塞特犬的出生队列中，甲状腺功能减退症的发生率为2.7％，对称甲癣发生率为8.9％，但是在这291只狗中，只有一只患有两种疾病。在DLA研究中，诊断出患有甲状腺功能减退症的狗的平均年龄在Gordon setter中为6.4岁（95％CI：5.6-7.2岁），在2000年为7.7岁（95％CI：7.2-8.2岁）。英语的二传手。在Gordon setter和English setter中与甲状腺功能减退最相关的DLA等位基因为DLA-DQB1 * 00201（OR？=？3.6，95％CI：2.1-6.4，p在Gordon setter中，单倍型DLA-DRB1 * 01801 / DQA1 * 00101 / DQB1 * 00802与对称性甲癣显着相关（OR？=？2.9，95 %% CI：1.7-5.2，p结论）甲状腺功能低下是一种复杂的疾病，其中DLA基因与其他基因一起可能参与了甲状made肉的发病。在戈登二传手中，一种与保护甲状腺功能低下有关的DLA单倍型也与对称甲甲made病有关，这些发现表明紧密联系的基因，而不是DLA基因本身或与之一起，可能与甲状腺功能低下和对称有关。在一个流行几种自身免疫性疾病的犬种中，在将DLA用作标记辅助选择工具之前，需要研究DLA基因与实际疾病之间的所有可能关联。

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