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首页> 外文期刊>Canine Genetics and Epidemiology >DNM1 mutation status, sex, and sterilization status of a cohort of Labrador retrievers with and without cranial cruciate ligament rupture
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DNM1 mutation status, sex, and sterilization status of a cohort of Labrador retrievers with and without cranial cruciate ligament rupture

机译：一组拉布拉多犬颅骨韧带断裂与不断裂的DNM1突变状态，性别和绝育状态

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BackgroundExercise-induced collapse (EIC) due to DNM1 mutation and rupture of the cranial cruciate ligament are both common syndromes in the Labrador retriever breed. A cohort of 313 Labradors was recruited based on their CCLR status and were subsequently genetically tested for EIC. Epidemiological aspects of the cohort were also described, including sex, sterilization status, and age at sterilization. ResultsNo sex difference was observed in dogs susceptible to EIC (homozygous for the mutant genotype) compared to dogs not susceptible to EIC (heterozygotes and dogs homozygous for the normal genotype). No evidence for association was detected between CCLR status and EIC status ( p =0.357), although the sample cohort was not of sufficient size to entirely rule out an association. A significant difference ( p =?0.031) was observed in the sex distribution of dogs affected with CCLR compared to those without CCLR. An increased number of female CCLR cases were observed compared to the number of female controls; male CCLR cases and controls were approximately the same number. When CCLR status was examined in each sex, no significant differences were observed between those that were sterilized and those that weren’t. However, for female dogs that were sterilized, CCLR cases were significantly higher in dogs sterilized at one year of age or younger compared to those sterilized when over the age of one year ( p =?0.0021, OR 4.30, 95% CI 1.55–12.72); for males, this finding was suggestive, but not statistically significant ( p =?0.0913, OR 3.57, 95% CI 0.809–14.476). ConclusionsCCLR is not associated with a large increase in EIC occurrence. Statistically, these two syndromes cannot be proven to be unrelated; however, concomitant occurrence of CCLR and EIC in Labrador retrievers is rare, despite the high prevalence of both syndromes in this breed. Epidemiological findings suggest that females may be over-represented in CCLR cases and that early sterilization (≤1 year) may increase the risk of Labradors developing CCLR later in life (particularly in females). These results should be considered preliminary and require confirmation in larger populations of Labrador retrievers.
机译：背景由于DNM1突变而导致的运动诱发的崩溃（EIC）和颅骨十字韧带的破裂都是拉布拉多犬品种中的常见综合征。根据其CCLR身份招募了313名拉布拉多族群，随后对其进行了EIC基因测试。还描述了该队列的流行病学方面，包括性别，绝育状态和绝育年龄。结果与不对EIC不敏感的狗（杂合子和正常基因纯合的狗）相比，对EIC敏感的狗（突变基因型为纯合子）没有性别差异。尽管样本队列的规模不足以完全排除关联，但未检测到CCLR状态与EIC状态之间存在关联的证据（p = 0.357）。与没有CCLR的狗相比，在受CCLR感染的狗的性别分布中观察到了显着差异（p =？0.031）。与女性对照组相比，女性CCLR病例增加。男性CCLR病例和对照的人数大致相同。在检查了每种性别的CCLR状态后，未消毒者与未消毒者之间没有发现显着差异。但是，对于经过消毒的雌犬，与一年以上进行消毒的犬相比，在一岁或更年轻的经过消毒的犬的CCLR病例要高得多（p =？0.0021，或4.30，95％CI 1.55-12.72）。 ）;对于男性而言，这一发现具有启发性，但无统计学意义（p =？0.0913，OR 3.57，95％CI 0.809-14.476）。结论CCLR与EIC发生率的大幅增加无关。从统计上讲，这两种综合症不能被证明是无关的;然而，尽管拉布拉多犬中两种综合征的患病率很高，但在拉布拉多犬中同时出现CCLR和EIC的情况很少。流行病学调查结果表明，在CCLR病例中女性可能过多，而早期绝育（≤1年）可能会增加Labradors在晚年发展CCLR的风险（尤其是女性）。这些结果应被认为是初步的，需要在更多的拉布拉多犬中进行确认。

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