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首页> 外文期刊>Behavioral and Brain Functions >The possible link between elevated serum levels of epithelial cell-derived neutrophil- activating peptide-78 (ENA-78/CXCL5) and autoimmunity in autistic children
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The possible link between elevated serum levels of epithelial cell-derived neutrophil- activating peptide-78 (ENA-78/CXCL5) and autoimmunity in autistic children

机译：自闭症儿童血清上皮细胞衍生的中性粒细胞激活肽-78（ENA-78 / CXCL5）水平升高与自身免疫之间的可能联系

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Background In autoimmune disorders, the underlying pathogenic mechanism is the formation of antigen-antibody complexes which trigger an inflammatory response by inducing the infiltration of neutrophils. Epithelial cell-derived neutrophil-activating peptide-78 (ENA-78) is a chemokine that recruits and activates neutrophils, thus it could play a pathogenic role in inflammation and autoimmune disorders. Some autistic children have elevated levels of brain specific auto-antibodies. We are the first to evaluate serum expression of ENA-78 and its relation to antineuronal auto-antibodies in autistic children. Methods Serum ENA-78 and antineuronal auto-antibodies were measured by ELISA test in 62 autistic children aged between 4–11 years and 62 health-matched controls. Results Serum levels of ENA-78 were significantly higher in autistic children than healthy controls (P? Conclusions Serum levels of ENA-78 were elevated in autistic children and they were significantly associated with the increased levels of serum antineuronal auto-antibodies. However, these data should be treated with caution until further research is conducted to determine the pathogenic role of ENA-78 in autism and its relation to brain specific auto-antibodies that have been found in some autistic children. The possible therapeutic role of ENA-78 antagonist in autistic children should be also studied.
机译：背景技术在自身免疫性疾病中，潜在的致病机制是抗原-抗体复合物的形成，其通过诱导嗜中性粒细胞的浸润而触发炎症反应。上皮细胞衍生的中性粒细胞激活肽-78（ENA-78）是一种趋化因子，可募集并激活中性粒细胞，因此可在炎症和自身免疫性疾病中发挥致病作用。一些自闭症儿童的脑特异性自身抗体水平升高。我们是第一个评估自闭症儿童中ENA-78的血清表达及其与抗神经元自身抗体的关系的人。方法采用ELISA法对62例4〜11岁的自闭症儿童和62例健康对照者进行血清ENA-78和抗神经元自身抗体的检测。结果自闭症儿童的血清ENA-78水平显着高于健康对照组（P？结论：自闭症儿童的血清ENA-78水平升高，并且与血清抗神经元自身抗体水平升高显着相关。在进一步研究确定ENA-78在自闭症中的致病作用及其与某些自闭症儿童中发现的脑特异性自身抗体的关系之前，应谨慎对待数据。自闭症儿童也应进行研究。

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