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首页> 外文期刊>Case Reports in Pediatrics >Liver Transplant in a Patient under Methylphenidate Therapy: A Case Report and Review of the Literature
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Liver Transplant in a Patient under Methylphenidate Therapy: A Case Report and Review of the Literature

机译：哌醋甲酯治疗患者的肝移植：一例报道并文献复习

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Background. Methylphenidate (MPH) is widely used in treating children with attention-deficit-hyperactivity disorder. Hepatotoxicity is a rare phenomenon; only few cases are described with no liver failure.Case. We report on the case of a 12-year-old boy who received MPH for attention-deficit-hyperactivity disorder. Two months later the patient presented with signs and symptoms of hepatitis and MPH was discontinued, showing progressive worsening and developing liver failure and a liver transplantation was required. Other causes of liver failure were ruled out and the liver biopsy was suggestive of drug toxicity.Discussion. One rare adverse reaction of MPH is hepatotoxicity. The review of the literature shows few cases of liver injury attributed to MPH; all of them recovered after withdrawing the treatment. The probable mechanism of liver injury was MPH direct toxicity to hepatocytes. In order to establish the diagnosis of MPH-induced liver injury, we used CIOMS/RUCAM scale that led to an assessment of “possible” relationship. This report provides the first published case of acute MPH-induced liver failure with successful hepatic transplantation.Conclusions. It is important to know that hepatotoxicity can occur in patients with MPH treatment and monitoring the liver’s function is highly recommended.
机译：背景。哌醋甲酯（MPH）被广泛用于治疗患有注意力缺陷多动障碍的儿童。肝毒性是一种罕见的现象。仅描述了几例无肝功能衰竭的病例。我们报道了一个12岁男孩因注意力缺陷多动障碍而接受MPH的病例。两个月后，出现肝炎体征和症状的患者停药，MPH停药，表现出进行性恶化和发展中的肝衰竭，需要进行肝移植。排除了其他肝功能衰竭的原因，肝活检提示药物毒性。 MPH的一种罕见的不良反应是肝毒性。文献综述显示，很少有病例归因于MPH。他们全部撤出治疗后都康复了。肝损伤的可能机制是MPH对肝细胞的直接毒性。为了确定MPH引起的肝损伤的诊断，我们使用CIOMS / RUCAM量表来评估“可能”的关系。该报告提供了成功发表肝移植的首例已发表的急性MPH诱发的肝衰竭病例。重要的是要知道在MPH治疗的患者中可能发生肝毒性，因此强烈建议监测肝功能。

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