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首页> 外文期刊>Catalysts >Polycyclic Ketone Monooxygenase (PockeMO): A Robust Biocatalyst for the Synthesis of Optically Active Sulfoxides
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Polycyclic Ketone Monooxygenase (PockeMO): A Robust Biocatalyst for the Synthesis of Optically Active Sulfoxides

机译：多环酮单加氧酶（PockeMO）：合成光学活性亚砜的稳健生物催化剂

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摘要

A recently discovered, moderately thermostable Baeyer-Villiger monooxygenase, polycyclic ketone monooxygenase (PockeMO), from Thermothelomyces thermophila has been employed as a biocatalyst in a set of asymmetric sulfoxidations. The enzyme was able to catalyze the oxidation of various alkyl aryl sulfides with good selectivities and moderate to high activities. The biocatalytic performance was able to be further increased by optimizing some reaction parameters, such as the addition of 10% v v ?1 of water miscible solvents or toluene, or by performing the conversion at a relatively high temperature (45 °C). PockeMO was found to display an optimum activity at sulfide concentrations of 50 mM, while it can also function at 200 mM. Taken together, the data show that PockeMO can be used as robust biocatalyst for the synthesis of optically active sulfoxides.
机译：最近从嗜热栖热菌中发现了一种适度热稳定的Baeyer-Villiger单加氧酶，即多环酮单加氧酶（PockeMO），已被用作一系列不对称硫氧化反应的生物催化剂。该酶能够以良好的选择性和中等至高活性催化各种烷基芳基硫醚的氧化。通过优化一些反应参数，例如添加10％v v？1的水混溶性溶剂或甲苯，或在相对较高的温度（45°C）下进行转化，可以进一步提高生物催化性能。发现PockeMO在50 mM的硫化物浓度下显示出最佳活性，而在200 mM下也能发挥作用。两者合计，数据显示PockeMO可用作合成旋光亚砜的强健生物催化剂。

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