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首页> 外文期刊>Catalysts >RNA-Cleaving DNAzymes: Old Catalysts with New Tricks for Intracellular and In Vivo Applications
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RNA-Cleaving DNAzymes: Old Catalysts with New Tricks for Intracellular and In Vivo Applications

机译：裂解RNA的DNA酶：用于细胞内和体内应用的具有新技术的旧催化剂

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摘要

DNAzymes are catalytically active DNA molecules that are normally isolated through in vitro selection methods, among which RNA-cleaving DNAzymes that catalyze the cleavage of a single RNA linkage embedded within a DNA strand are the most studied group of this DNA enzyme family. Recent advances in DNA nanotechnology and engineering have generated many RNA-cleaving DNAzymes with unique recognition and catalytic properties. Over the past decade, numerous RNA-cleaving, DNAzymes-based functional probes have been introduced into many research areas, such as in vitro diagnostics, intracellular imaging, and in vivo therapeutics. This review focus on the fundamental insight into RNA-Cleaving DNAzymes and technical tricks for their intracellular and in vivo applications, highlighting the recent progress in the clinical trial of RNA-Cleaving DNAzymes with selected examples. The challenges and opportunities for the future translation of RNA-cleaving DNAzymes for biomedicine are also discussed.
机译：DNA酶是通常通过体外选择方法分离的具有催化活性的DNA分子，其中催化DNA链内嵌入的单个RNA键断裂的RNA裂解DNA酶是该DNA酶家族中研究最多的组。 DNA纳米技术和工程学的最新进展产生了许多具有独特识别和催化特性的RNA裂解DNA酶。在过去的十年中，许多基于RNA酶，基于DNA酶的功能性探针已被引入许多研究领域，例如体外诊断，细胞内成像和体内治疗。这篇综述的重点是对RNA裂解DNA酶的基本了解以及在细胞内和体内应用的技术技巧，并通过一些实例突出了RNA裂解DNA酶的临床试验的最新进展。还讨论了用于生物医学的RNA切割DNA酶的未来翻译的挑战和机遇。

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