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Osteoblasts and their applications in bone tissue engineering

机译:成骨细胞及其在骨组织工程中的应用

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Abstract: Tissue engineering is an emerging therapy that offers a new solution to patients suffering from bone loss. It utilizes cells derived from such sources as a patient's own bone or bone marrow, which are laboratory-isolated, grown (so they multiply in number), and placed onto a degradable material, or scaffold, that has mechanical/chemical properties appropriate to the bone section that it is replacing. The cells plus the scaffold are then grown in a container, or bioreactor, which is necessary as it provides the correct environment required for the cells to proliferate, differentiate, and to produce extracellular matrix. The following review focuses on the use of osteoblasts for bone tissue engineering.
机译:摘要:组织工程学是一种新兴的疗法,它为骨丢失的患者提供了新的解决方案。它利用源自患者自身骨骼或骨髓等来源的细胞,这些细胞经过实验室隔离,生长(使其数量成倍增加),并置于具有适合于人体的机械/化学特性的可降解材料或支架上。它要替换的骨骼部分。然后将细胞和支架一起在容器或生物反应器中生长,这是必需的,因为它提供了细胞增殖,分化和产生细胞外基质所需的正确环境。以下评论着重于将成骨细胞用于骨组织工程。

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