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New developments in C5a receptor signaling

机译：C5a受体信号传导的新进展

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Abstract: Complement activation usually results in the formation of complement fragment 5a (C5a) that interacts with its two receptors, C5aR and C5L2. These receptors belong to the rhodopsin family of G protein-coupled seven transmembrane-containing receptors. C5aR and C5L2 are expressed on/in a wide variety of cells and tissues. Interaction of C5a with C5aR leads to many pleiotropic effects, including the release of cytokines and chemokines and recruitment of inflammatory cells. In certain circumstances, C5a–C5aR interactions can also result in pathophysiological changes as seen in sepsis, rheumatoid arthritis, asthma, acute lung injury and ischemia-reperfusion injury. This overview of the C5a–C5aR interactions describes how such interactions facilitate the pivotal role the complement system plays in the host's innate and adaptive responses.
机译：摘要：补体激活通常会导致补体片段5a（C5a）与其两个受体C5aR和C5L2相互作用而形成。这些受体属于视紫红质家族的G蛋白偶联的七个跨膜受体。 C5aR和C5L2在多种细胞和组织中表达。 C5a与C5aR的相互作用导致许多作用，包括细胞因子和趋化因子的释放以及炎症细胞的募集。在某些情况下，C5a–C5aR相互作用还可能导致病理生理变化，如败血症，类风湿性关节炎，哮喘，急性肺损伤和缺血再灌注损伤。 C5a–C5aR相互作用的概述概述了这种相互作用如何促进补体系统在宿主的先天和适应性反应中起关键作用。

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