CD10 Expression in Non-Small Cell Lung Cancer

GlenKristiansen; KarstenSchlüns; YuYongwei; ManfredDietel; IverPetersen

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CD10 Expression in Non-Small Cell Lung Cancer

机译：CD10在非小细胞肺癌中的表达

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CD10 is a cell surface endopeptidase that inactivates various potentially growth stimulatory peptides. In lung cancer cell lines this downregulation has been associated with increased proliferation. Downregulation of CD10 in lung cancer tissue is described, suggesting a potential role in carcinogenesis and a possible use of CD10 as a prognostic marker. We aimed to determine the rate of CD10 expression in our non‐small cell lung cancer (NSCLC) collection and to clarify its correlation with clinicopathological parameters and patient survival. 114 NSCLC were analysed immunohistochemically using a monoclonal CD10 antibody (clone NCL‐CD10‐270) on an NSCLC tissue micro array. The staining was semiquantitatively scored. CD10 expression was observed in 19% of cases, without any significant association with tumour type, ‐size, ‐grading, nodal status, clinical stage, and patient survival time. We conclude that a diagnostic use of CD10 immunostaining in NSCLC is unlikely.

机译：CD10是一种细胞表面内肽酶，可以使各种潜在的生长刺激肽失活。在肺癌细胞系中，这种下调与增殖增加有关。描述了肺癌组织中CD10的下调，提示其在致癌作用中的潜在作用以及CD10作为预后标志物的可能用途。我们旨在确定非小细胞肺癌（NSCLC）集合中CD10表达的速率，并阐明其与临床病理参数和患者生存率的相关性。使用单克隆CD10抗体（克隆NCL-CD10-270）在NSCLC组织微阵列上对114例NSCLC进行了免疫组织化学分析。染色是半定量的。在19％的病例中观察到CD10表达，与肿瘤类型，大小，分级，淋巴结状态，临床分期和患者生存时间没有任何显着相关性。我们得出结论，不可能在NSCLC中诊断CD10免疫染色的用途。

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《Cellular Oncology: Analytical Cellular Pathology》 |2002年第1期|共6页
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GlenKristiansen; KarstenSchlüns; YuYongwei; ManfredDietel; IverPetersen;
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中图分类临床医学;
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1. hsa-miR29b, a critical downstream target of non-canonical Wnt signaling, plays an anti-proliferative role in non-small cell lung cancer cells via targeting MDM2 expression hsa-miR29b, a critical downstream target of non-canonical Wnt signaling, plays an anti-proliferative role in non-small cell lung cancer cells via targeting MDM2 expression hsa-miR29b, a critical downstream target of non-canonical Wnt signaling, plays an anti-proliferative role in non-small cell lung cancer cells via targeting MDM2 expression [J] . Michael G. Edwards, Katherine Vandervest, John Arcaroli, Biology Open . 2013,第7期

机译：hsa-miR29b（非经典Wnt信号的关键下游靶标）通过靶向MDM2表达在非小细胞肺癌细胞中发挥抗增殖作用hsa-miR29b（非经典Wnt信号的关键下游靶标）通过靶向MDM2表达在非小细胞肺癌细胞中的抗增殖作用hsa-miR29b（非经典Wnt信号的关键下游靶点）通过靶向MDM2表达在非小细胞肺癌细胞中发挥抗增殖作用
2. CD10 expression in non-small cell lung cancer. [J] . Kristiansen G, Schluns K, Yongwei Y, Analytical cellular pathology: the journal of the European Society for Analytical Cellular Pathology . 2002,第1期

机译：CD10在非小细胞肺癌中的表达。
3. CD10 expression in epithelial and stromal cells of non-small cell lung carcinoma (NSCLC): a clinic and pathologic correlation. [J] . Duygu Gürel, Aydanur Karg?, Ilg?n Karaman, Pathology oncology research: POR . 2012,第2期

机译：非小细胞肺癌（NSCLC）上皮和基质细胞中CD10表达的临床和病理相关性。
4. Gene expression profiles predict survival of patients with advanced non-small cell lung cancers [C] . Harun Roslan, Hadi Jalal, Mhazir Nur Shukriyah, 2011 Fourth International Conference on Modeling, Simulation and Applied Optimization . 2011

机译：基因表达谱预测晚期非小细胞肺癌患者的生存
5. Analysis of TWEAK Receptor (Fn14) Expression and Function in Non-small Cell Lung Cancer Cells. [D] . Cheng, Emily. 2014

机译：非小细胞肺癌细胞中TWEAK受体（Fn14）表达和功能的分析。
6. CD10 Expression in Non-Small Cell Lung Cancer [O] . Glen Kristiansen, Karsten Schlüns, Yu Yongwei, 2002

机译：CD10在非小细胞肺癌中的表达
7. OPN-a splicing variant expression in non-small cell lung cancer and its effects on the bone metastatic abilities of lung cancer cells in vitro [O] . Hao, Chengcheng, Cui, Yuxin, Hu, M., 2017

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CD10 Expression in Non-Small Cell Lung Cancer

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