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The chromosomal passenger complex and the spindle assembly checkpoint: kinetochore-microtubule error correction and beyond

机译：染色体乘客复合体和纺锤体装配检查点：动臂-微管误差校正及其他

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摘要

During mitosis, correct bipolar chromosome attachment to the mitotic spindle is an essential prerequisite for the equal segregation of chromosomes. The spindle assembly checkpoint can prevent chromosome segregation as long as not all chromosome pairs have obtained bipolar attachment to the spindle. The chromosomal passenger complex plays a crucial role during chromosome alignment by correcting faulty chromosome-spindle interactions (e.g. attachments that do not generate tension). In the process of doing so, the chromosomal passenger complex generates unattached chromosomes, a specific situation that is known to promote checkpoint activity. However, several studies have implicated an additional, more direct role for the chromosomal passenger complex in enforcing the mitotic arrest imposed by the spindle assembly checkpoint. In this review, we discuss the different roles played by the chromosomal passenger complex in ensuring proper mitotic checkpoint function. Additionally, we discuss the possibility that besides monitoring the presence of unattached kinetochores, the spindle assembly checkpoint may also be capable of responding to chromosome-microtubule interactions that do not generate tension and we propose experimental set-ups to study this.
机译：在有丝分裂期间，正确的双极染色体附着在有丝分裂纺锤体上是染色体均等分离的必要前提。只要并非所有染色体对都获得了与主轴的双极连接，纺锤体装配检查点就可以防止染色体分离。染色体乘客复合体通过纠正错误的染色体-纺锤体相互作用（例如不会产生张力的附件）在染色体比对过程中发挥关键作用。在这样做的过程中，染色体乘客复合体会生成未连接的染色体，这是一种已知的特定情况，可促进检查站的活动。但是，一些研究表明，染色体乘客复合体在执行纺锤体装配检查点施加的有丝分裂阻滞中具有其他更直接的作用。在这篇综述中，我们讨论了染色体乘客复合体在确保适当的有丝分裂检查点功能中所起的不同作用。此外，我们讨论了以下可能性：除了监视未连接的动植物的存在以外，纺锤体装配检查点还可能能够响应不会产生张力的染色体-微管相互作用，我们提出了实验装置来对此进行研究。

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