Damaged-DNA Binding Protein-2 Drives Apoptosis Following DNA Damage

Srilata Bagchi; Pradip Raychaudhuri

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Damaged-DNA Binding Protein-2 Drives Apoptosis Following DNA Damage

机译：DNA损伤后，DNA结合蛋白2驱动细胞凋亡。

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Apoptosis induced by DNA damage is an important mechanism of tumor suppression and it is significant also in cancer chemotherapy. Mammalian cells activate the pathways of p53 to induce apoptosis of cells harboring irreparable DNA damages. While p53 induces expression of various pro-apoptotic genes and directly participates in the disruption of mitochondrial membrane polarization, it also increases expression of the cell cycle inhibitor p21 that is a dominant inhibitor of caspase-activation and apoptosis. Here we discuss how Damaged-DNA Binding Protein-2 (DDB2) subdues the level of p21 in cells harboring irreparable DNA damage to support activation of the caspases. We speculate a model in which DDB2 detects and couples the presence of un-repaired DNA damages to the proteolysis of p21, leading to the induction of apoptosis.

机译：DNA损伤诱导的细胞凋亡是抑制肿瘤的重要机制，在癌症化疗中也很重要。哺乳动物细胞激活p53的通路，诱导具有不可修复的DNA损伤的细胞凋亡。虽然p53诱导各种促凋亡基因的表达并直接参与线粒体膜极化的破坏，但它也增加了细胞周期抑制剂p21的表达，后者是caspase激活和凋亡的主要抑制剂。在这里，我们讨论受损DNA结合蛋白2（DDB2）如何抑制细胞中p21的水平，该细胞具有不可修复的DNA损伤以支持胱天蛋白酶的激活。我们推测一个模型，其中DDB2检测并耦合未修复的DNA损伤的存在对p21的蛋白水解，导致细胞凋亡的诱导。

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《Cell Division》 |2010年第1期|共页
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Srilata Bagchi; Pradip Raychaudhuri;
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中图分类细胞生物学;
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1. DDB2 (damaged-DNA binding protein 2) in nucleotide excision repair and DNA damage response. [J] . Stoyanova T, Roy N, Kopanja D, Cell cycle . 2009,第24期

机译：DDB2（受损的DNA结合蛋白2）在核苷酸切除修复和DNA损伤反应中的作用。
2. The p48 subunit of the damaged-DNA binding protein DDB associates with the CBP/p300 family of histone acetyltransferase. [J] . Datta A, Bagchi S, Nag A, Mutation Research: International Journal on Mutagenesis, Chromosome Breakage and Related Subjects . 2001,第2期

机译：受损的DNA结合蛋白DDB的p48亚基与组蛋白乙酰转移酶CBP / p300家族相关。
3. Identification of a damaged-DNA binding domain of the XPA protein. [J] . Kuraoka I, Morita EH, Saijo M, Mutation Research: International Journal on Mutagenesis, Chromosome Breakage and Related Subjects . 1996,第1期

机译：鉴定XPA蛋白的受损DNA结合结构域。
4. rSNP_Guide: Meta-Tools Predicting of Regulatory DNA Signals Damaged/Appeared Due to Single Nucleotide Mutation by Alterations in Pattern of DNA Binding to Nuclear Proteins [C] . Mikhail Ponomarenko, Tatyana Merkulova, Julia Ponomarenko, International NAISO(Natural amp; Artificial Intelligence Systems Organization) Congress on Information Science Innovations Mar 17-21, 2001 Dubai, U.A.E. . 2001

机译：rSNP_Guide：预测由于单核苷酸突变导致DNA结合核蛋白模式改变而破坏/显示的调控DNA信号的元工具
5. Single molecule studies of damaged recognition by the human UV-damaged DNA-binding protein (UV-DDB) [D] . Ghodke, Harshad 2013

机译：人类紫外线损伤的DNA结合蛋白（UV-DDB）识别识别受损的单分子研究
6. Damaged-DNA Binding Protein-2 Drives Apoptosis Following DNA Damage [O] . Srilata Bagchi, Pradip Raychaudhuri 2010

机译：DNA损伤后DNA结合蛋白2驱动细胞凋亡
7. Damaged-DNA Binding Protein-2 Drives Apoptosis Following DNA Damage [O] . Srilata Bagchi, Pradip Raychaudhuri 2010

机译：DNA损伤后DNA结合蛋白2驱动细胞凋亡

Damaged-DNA Binding Protein-2 Drives Apoptosis Following DNA Damage

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