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首页> 外文期刊>Cell discovery. >Disruption of glial cell development by Zika virus contributes to severe microcephalic newborn mice
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Disruption of glial cell development by Zika virus contributes to severe microcephalic newborn mice

机译：寨卡病毒破坏神经胶质细胞发育导致严重的小头畸形新生小鼠

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The causal link between Zika virus (ZIKV) infection and microcephaly has raised alarm worldwide. Microglial hyperplasia, reactive gliosis, and myelination delay have been reported in ZIKV-infected microcephalic fetuses. However, whether and how ZIKV infection affects glial cell development remain unclear. Here we show that ZIKV infection of embryos at the later stage of development causes severe microcephaly after birth. ZIKV infects the glial progenitors during brain development. Specifically, ZIKV infection disturbs the proliferation and differentiation of the oligodendrocyte progenitor cells and leads to the abolishment of oligodendrocyte development. More importantly, a single intraperitoneal injection of pregnant mice with a human monoclonal neutralizing antibody provides full protection against ZIKV infection and its associated damages in the developing fetuses. Our results not only provide more insights into the pathogenesis of ZIKV infection, but also present a new model for the preclinical test of prophylactic and therapeutic agents against ZIKV infection.
机译：寨卡病毒（ZIKV）感染与小头畸形之间的因果关系在全世界引起了警报。 ZIKV感染的小头胎儿中已报告了小胶质增生，反应性神经胶质增生和髓鞘延迟。但是，ZIKV感染是否以及如何影响神经胶质细胞发育尚不清楚。在这里，我们显示ZIKV胚胎在发育的后期感染会导致出生后严重的小头畸形。 ZIKV在大脑发育过程中感染神经胶质祖细胞。具体而言，ZIKV感染扰乱了少突胶质细胞祖细胞的增殖和分化，并导致少突胶质细胞发育的取消。更重要的是，一次腹膜内注射人单克隆中和抗体的妊娠小鼠可为ZIKV感染及其在发育中的胎儿中的相关损害提供全面保护。我们的结果不仅为ZIKV感染的发病机理提供了更多的见识，而且还为预防和治疗ZIKV感染的药物提供了新的临床前测试模型。

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