...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Cell Division >FAT10, a gene up-regulated in various cancers, is cell-cycle regulated
【24h】

FAT10, a gene up-regulated in various cancers, is cell-cycle regulated

机译：FAT10是一种在多种癌症中上调的基因，受细胞周期调控

获取原文
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Background FAT10 is a member of the ubiquitin-like-modifier family of proteins. Over-expression of the FAT10 gene was observed in the tumors of several epithelial cancers. High FAT10 expression was found to lead to increased chromosome instability via the reduction in the kinetochore localization of MAD2 during the prometaphase stage of the cell-cycle. FAT10 expression was also previously reported to be regulated by cytokines and p53. Results Here, we report that FAT10 expression is regulated at the protein and transcript level during cell-cycle with highest expression observed during the S-phase of the cell-cycle. The distal region between -1997 to -975 bp from the transcription start site of the FAT10 promoter may play a role in the repression of FAT10 expression during G2/M phase of the cell-cycle. Conclusion FAT10 expression is regulated during cell-cycle.
机译：背景FAT10是蛋白质的泛素样修饰物家族的成员。在几种上皮癌的肿瘤中观察到了FAT10基因的过表达。发现高FAT10表达通过在细胞周期的前中期阶段减少MAD2的线粒体定位而导致染色体不稳定性增加。 FAT10的表达以前也据报道受细胞因子和p53的调节。结果在这里，我们报道FAT10的表达在细胞周期中受到蛋白质和转录水平的调节，在细胞周期的S期中观察到最高的表达。 FAT10启动子的转录起始位点-1997至-975 bp之间的远侧区域可能在细胞周期的G2 / M期抑制FAT10表达。结论FAT10的表达在细胞周期中受到调控。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号