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Meiosis specific coiled-coil proteins in Shizosaccharomyces pombe

机译:粟酒裂殖酵母中减数分裂特异的卷曲螺旋蛋白

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Many meiosis-specific proteins in Schizosaccharomyces pombe contain coiled-coil motifs which play essential roles for meiotic progression. For example, the coiled-coil motifs present in Meu13 and Mcp7 are required for their function as a putative recombinase cofactor complex during meiotic recombination. Mcp6/Hrs1 and Mcp5/Num1 control horsetail chromosome movement by astral microtubule organization and anchoring dynein respectively. Dhc1 and Ssm4 are also required for horsetail chromosome movement. It is clear from these examples that the coiled-coil motif in these proteins plays an important role during the progression of cells through meiosis. However, there are still many unanswered questions on how these proteins operate. In this paper, we briefly review recent studies on the meiotic coiled-coil proteins in Sz. pombe.
机译:粟酒裂殖酵母中许多减数分裂特异的蛋白质都含有卷曲螺旋基序,这些基序对减数分裂的进程起着至关重要的作用。例如,存在于Meu13和Mcp7中的卷曲螺旋基序是它们在减数分裂重组过程中作为假定的重组酶辅因子复合物所必需的。 Mcp6 / Hrs1和Mcp5 / Num1分别通过星状微管组织和锚定动力蛋白控制马尾染色体运动。马尾染色体运动也需要Dhc1和Ssm4。从这些例子可以清楚地看出,这些蛋白质中的卷曲螺旋基序在细胞通过减数分裂的过程中起着重要的作用。但是,关于这些蛋白质如何运作,仍然存在许多悬而未决的问题。在本文中,我们简要回顾了有关Sz中减数分裂卷曲螺旋蛋白的最新研究。庞贝。

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