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Dynamic transcriptomic m6A decoration: writers, erasers, readers and functions in RNA metabolism

机译:动态转录组m6A修饰:RNA代谢中的书写器,橡皮擦,读取器和功能

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N6-methyladenosine (m6A) is a chemical modification present in multiple RNA species, being most abundant in mRNAs. Studies on enzymes or factors that catalyze, recognize, and remove m6A have revealed its comprehensive roles in almost every aspect of mRNA metabolism, as well as in a variety of physiological processes. This review describes the current understanding of the m6A modification, particularly the functions of its writers, erasers, readers in RNA metabolism, with an emphasis on its role in regulating the isoform dosage of mRNAs.
机译:N6-甲基腺苷(m6A)是存在于多种RNA中的一种化学修饰,在mRNA中含量最高。对催化,识别和去除m6A的酶或因子的研究表明,它在mRNA代谢的几乎每个方面以及各种生理过程中都具有综合作用。这篇综述描述了目前对m6A修饰的理解,特别是其在RNA代谢中的书写者,擦除者和阅读者的功能,重点是其在调节mRNA异构体剂量中的作用。

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