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Proliferation/Quiescence: When to start? Where to stop? What to stock?

机译：增殖/静止：何时开始？在哪里停下来？库存什么？

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摘要

The cell cycle is a tightly controlled series of events that ultimately lead to cell division. The literature deciphering the molecular processes involved in regulating the consecutive cell cycle steps is colossal. By contrast, much less is known about non-dividing cellular states, even if they concern the vast majority of cells, from prokaryotes to multi-cellular organisms. Indeed, cells decide to enter the division cycle only if conditions are favourable. Otherwise they may enter quiescence, a reversible non-dividing cellular state. Recent studies in yeast have shed new light on the transition between proliferation and quiescence, re-questioning the notion of cell cycle commitment. They also indicate a predominant role for cellular metabolic status as a major regulator of quiescence establishment and exit. Additionally, a growing body of evidence indicates that environmental conditions, and notably the availability of various nutrients, by impinging on specific metabolic routes, directly regulate specific cellular re-organization that occurs upon proliferation/quiescence transitions.
机译：细胞周期是一系列严格控制的事件，最终导致细胞分裂。破译涉及调节连续细胞周期步骤的分子过程的文献非常丰富。相比之下，对于非分裂的细胞状态，即使它们涉及从原核生物到多细胞生物的绝大多数细胞，人们所知甚少。确实，只有在条件有利的情况下，细胞才决定进入分裂周期。否则它们可能进入静止状态，即可逆的非分裂细胞状态。酵母的最新研究为增殖和静止之间的过渡提供了新的思路，再次质疑了细胞周期承诺的概念。它们还表明细胞代谢状态作为静止建立和退出的主要调节剂的主要作用。另外，越来越多的证据表明，环境条件，尤其是各种营养物的可用性，通过影响特定的代谢途径，直接调节了在增殖/静止转变时发生的特定细胞重组。

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