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首页> 外文期刊>American Journal of Physiology >Dual effect of HGF on satellite/myogenic cell quiescence. Focus on 'High concentrations of HGF inhibit skeletal muscle satellite cell proliferation in vitro by inducing expression of myostatin: a possible mechanism for reestablishing satellite cell quiescence in vivo'.
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Dual effect of HGF on satellite/myogenic cell quiescence. Focus on 'High concentrations of HGF inhibit skeletal muscle satellite cell proliferation in vitro by inducing expression of myostatin: a possible mechanism for reestablishing satellite cell quiescence in vivo'.

机译：HGF对卫星/成肌细胞静止的双重作用。专注于“高浓度的HGF通过诱导肌生长抑制素的表达在体外抑制骨骼肌卫星细胞的增殖：在体内重建卫星细胞静止的可能机制”。

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摘要

adult skeletal muscle shows a very high level of plasticity that is necessary for adaptation to various conditions. Moreover, it possesses the remarkable capacity to regenerate after injury, and such plasticity derives from the properties of satellite cells-a group of (Jells that restore muscle function throughout their lifespan. Normally quiescent under steady-state conditions, satellite cells are activated following muscle damage or exercise and then begin to proliferate. Expansion of these myogenic progenitors promotes muscle repair and regeneration by committing them to myogenic differentiation while a subset do not differentiate but instead, replenish the satellite cell pool (8, 17). Although myogenic cell proliferation and differentiation have been extensively studied, the mechanisms that mediate the regulation of exit from and entry into quiescence are less characterized.
机译：成年骨骼肌显示出非常高的可塑性，这是适应各种条件所必需的。此外，它具有显着的损伤后再生能力，而这种可塑性源自卫星细胞的特性（一组在整个生命周期中恢复肌肉功能的胶质。通常在稳态条件下静止，卫星细胞在肌肉中被激活）。这些成肌祖细胞的扩张通过使它们发生成肌分化而促进肌肉修复和再生，而一部分亚种不分化而是代之以补充卫星细胞池（8、17）。对分化的研究已得到广泛研究，而介导退出和进入静止的调节的机制的特征则较少。

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