• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Cellular Oncology: Analytical Cellular Pathology >Predictive Value of Tumor Load in Breast Cancer Sentinel Lymph Nodes for Second Echelon Lymph Node Metastases
【24h】

Predictive Value of Tumor Load in Breast Cancer Sentinel Lymph Nodes for Second Echelon Lymph Node Metastases

机译：乳腺癌前哨淋巴结中肿瘤负荷对第二梯队淋巴结转移的预测价值

获取原文
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Background: The need for routine axillary lymph node dissection (ALND) in patients with invasive breast cancer and low-volume sentinel node (SN) involvement is questionable. Accurate prediction of second echelon lymph node involvement could identify those patients most likely to benefit from ALND.Methods: A consecutive series of 317 patients with invasive breast cancer and a tumor positive axillary SN followed by ALND was reviewed. Clinicopathologic features of the primary tumor and the SN were assessed as possible predictors of second echelon lymph node involvement.Results: Second echelon metastases were found in 116/317 cases (36.6%). Frequency of second echelon lymph node involvement in patients with isolated tumor cells (ITC,N= 23), micro- (N= 101) and macrometastases (N= 193) was 13%, 20% and 48%, respectively (p< 0.001). Based on the area % of SN occupied by tumor no subgroup of patients could be selected with less than 20% second echelon lymph node involvement. However, none of the patients with SN ITC or micrometastases and a primary tumor size ≤1 cm (N = 12, 3.8%) had second echelon lymph node involvement.Conclusions: Accurately measured SN tumor load predicts second echelon lymph node involvement. However, even in patients with ITC, the second echelon lymph nodes are involved in 13% justifying ALND.
机译：背景：浸润性乳腺癌和低容量前哨淋巴结（SN）患者是否需要常规腋窝淋巴结清扫术（ALND）值得怀疑。方法：回顾性分析了317例浸润性乳腺癌，腋窝SN阳性的继发性ALND患者。评估原发肿瘤和SN的临床病理特征可能是第二梯形淋巴结受累的预测指标。结果：116/317例发现第二梯形转移（36.6％）。分离的肿瘤细胞（ITC，N = 23），微小转移（N = 101）和宏观转移（N = 193）的患者第二级淋巴结受累的频率分别为13％，20％和48％（p <0.001） ）。根据肿瘤所占的SN面积百分比，不能选择第二梯形淋巴结受累少于20％的患者亚组。然而，SN ITC或微转移灶且原发肿瘤大小≤1cm（N = 12，3.8％）的患者均无第二梯形淋巴结受累。结论：准确测量的SN肿瘤负荷可预测第二梯形淋巴结受累。但是，即使在ITC患者中，第二梯形淋巴结也涉及13％的ALND证明。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号